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Articles Published Processes
9/24/2025 3:48:37 AM | Browse: 181 | Download: 867
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Received |
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2025-05-09 08:50 |
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Peer-Review Started |
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2025-05-09 08:51 |
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First Decision by Editorial Office Director |
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2025-06-05 08:25 |
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Return for Revision |
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2025-06-05 08:25 |
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Revised |
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2025-06-18 07:29 |
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Publication Fee Transferred |
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2025-06-26 06:44 |
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Second Decision by Editor |
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2025-08-13 05:16 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-08-20 08:57 |
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Articles in Press |
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2025-08-20 08:57 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-09-03 08:21 |
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Publish the Manuscript Online |
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2025-09-24 03:48 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Basic Study |
| Article Title |
Exercise combined with induced pluripotent stem cells enhances the Wnt1-Lmx1a loop in the midbrain of Parkinsonian mice to alleviate Parkinsonian symptoms
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xing Jiang, Zhi-Min Lu, Qing-Lu Wang, Ying Luo and Jie Zhang |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Central Government Guides Local Science and Technology Development Funds |
YDZX2022091 |
| General Program of Natural Sciences of Qilu Medical University |
X24ZKQN03 |
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| Corresponding Author |
Jie Zhang, College of Medical Laboratory, Qilu Medical University, No. 2018 Jiangmenglu Road, Zibo 250300, Shandong Province, China. zhangjie@qlmu.edu.cn |
| Key Words |
Parkinson’s disease; Induced pluripotent stem cells; Epinephrine; Wnt1; Lmx1a; Exercise |
| Core Tip |
This study explores the combined therapeutic effect of exercise and induced pluripotent stem cells (iPSCs) in a Parkinson’s disease mouse model. Exercise alone enhances motor function and activates the Wnt signaling pathway, increasing adrenaline and Wnt1 levels. Combining exercise with iPSC treatment further boosts the Wnt1-Lmx1a regulatory loop, promoting iPSC differentiation into dopaminergic neurons and significantly improving motor function. |
| Publish Date |
2025-09-24 03:48 |
| Citation |
Jiang X, Lu ZM, Wang QL, Luo Y, Zhang J. Exercise combined with induced pluripotent stem cells enhances the Wnt1-Lmx1a loop in the midbrain of Parkinsonian mice to alleviate Parkinsonian symptoms. World J Stem Cells 2025; 17(9): 109330
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| URL |
https://www.wjgnet.com/1948-0210/full/v17/i9/109330.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v17.i9.109330 |
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