BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
9/24/2025 3:48:37 AM | Browse: 100 | Download: 450
 |
Received |
|
2025-05-09 08:50 |
|
Peer-Review Started |
|
2025-05-09 08:51 |
|
First Decision by Editorial Office Director |
|
2025-06-05 08:25 |
|
Return for Revision |
|
2025-06-05 08:25 |
|
Revised |
|
2025-06-18 07:29 |
|
Publication Fee Transferred |
|
2025-06-26 06:44 |
|
Second Decision by Editor |
|
2025-08-13 05:16 |
 |
Second Decision by Editor-in-Chief |
|
|
|
Final Decision by Editorial Office Director |
|
2025-08-20 08:57 |
|
Articles in Press |
|
2025-08-20 08:57 |
|
Edit the Manuscript by Language Editor |
|
|
|
Typeset the Manuscript |
|
2025-09-03 08:21 |
|
Publish the Manuscript Online |
|
2025-09-24 03:48 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Basic Study |
| Article Title |
Exercise combined with induced pluripotent stem cells enhances the Wnt1-Lmx1a loop in the midbrain of Parkinsonian mice to alleviate Parkinsonian symptoms
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xing Jiang, Zhi-Min Lu, Qing-Lu Wang, Ying Luo and Jie Zhang |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Central Government Guides Local Science and Technology Development Funds |
YDZX2022091 |
| General Program of Natural Sciences of Qilu Medical University |
X24ZKQN03 |
|
| Corresponding Author |
Jie Zhang, College of Medical Laboratory, Qilu Medical University, No. 2018 Jiangmenglu Road, Zibo 250300, Shandong Province, China. zhangjie@qlmu.edu.cn |
| Key Words |
Parkinson’s disease; Induced pluripotent stem cells; Epinephrine; Wnt1; Lmx1a; Exercise |
| Core Tip |
This study explores the combined therapeutic effect of exercise and induced pluripotent stem cells (iPSCs) in a Parkinson’s disease mouse model. Exercise alone enhances motor function and activates the Wnt signaling pathway, increasing adrenaline and Wnt1 levels. Combining exercise with iPSC treatment further boosts the Wnt1-Lmx1a regulatory loop, promoting iPSC differentiation into dopaminergic neurons and significantly improving motor function. |
| Publish Date |
2025-09-24 03:48 |
| Citation |
Jiang X, Lu ZM, Wang QL, Luo Y, Zhang J. Exercise combined with induced pluripotent stem cells enhances the Wnt1-Lmx1a loop in the midbrain of Parkinsonian mice to alleviate Parkinsonian symptoms. World J Stem Cells 2025; 17(9): 109330 |
| URL |
https://www.wjgnet.com/1948-0210/full/v17/i9/109330.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v17.i9.109330 |
All content on this site: Copyright © 1993-2026 Baishideng Publishing Group Inc, its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open access content, the relevant licensing terms apply.
