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Articles Published Processes
10/25/2025 1:11:34 AM | Browse: 210 | Download: 358
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Received |
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2025-05-14 03:08 |
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Peer-Review Started |
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2025-05-14 03:09 |
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First Decision by Editorial Office Director |
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2025-06-10 04:50 |
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Return for Revision |
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2025-06-10 04:50 |
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Revised |
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2025-06-24 03:30 |
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Publication Fee Transferred |
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2025-07-07 06:26 |
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Second Decision by Editor |
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2025-09-03 02:54 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-09-04 10:32 |
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Articles in Press |
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2025-09-04 10:32 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-10-15 07:32 |
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Publish the Manuscript Online |
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2025-10-25 01:11 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Basic Study |
| Article Title |
Synovial mesenchymal stem cell-derived exosomes delivering GRPEL1 activate PINK1-mediated mitophagy to promote cartilage repair in arthritis
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Cheng-Hao Xiang, Li Zou, Zhao-Gang Huang, Guo-Jun Zhang, Hui-Long Zeng, Ze-Xing He and Zhang-Sheng Dai |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Scientific Research Project of the Traditional Chinese Medicine Administration of Hubei Provincial Health Commission |
ZY2025L268 |
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| Corresponding Author |
Zhang-Sheng Dai, Chief Physician, Department of Orthopedics, The Second Affiliated Hospital of Fujian Medical University, No. 950 Donghai Avenue, Quanzhou 362000, Fujian Province, China. daizhangsheng@126.com |
| Key Words |
Osteoarthritis; Exosomes; Synovial mesenchymal stem cell; Cartilage repair; GrpE-like 1; Phosphatase and tensin homolog-induced putative kinase 1 |
| Core Tip |
This study demonstrates that synovial mesenchymal stem cell-derived exosomes engineered to deliver GrpE-like 1 effectively enhance phosphatase and tensin homolog-induced putative kinase 1-mediated mitophagy, promoting cartilage repair in osteoarthritis. By integrating bioinformatics, in vitro chondrocyte assays, and in vivo rat models, the findings reveal a novel mechanism by which GrpE-like 1 activates mitochondrial quality control and reduces oxidative stress. This work introduces a promising exosome-based therapeutic strategy that targets mitochondrial dysfunction, advancing the development of disease-modifying treatments beyond current symptomatic approaches for osteoarthritis. |
| Publish Date |
2025-10-25 01:11 |
| Citation |
Xiang CH, Zou L, Huang ZG, Zhang GJ, Zeng HL, He ZX, Dai ZS. Synovial mesenchymal stem cell-derived exosomes delivering GRPEL1 activate PINK1-mediated mitophagy to promote cartilage repair in arthritis. World J Stem Cells 2025; 17(10): 109369 |
| URL |
https://www.wjgnet.com/1948-0210/full/v17/i10/109369.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v17.i10.109369 |
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