Publication Name	World Journal of Nephrology
Manuscript ID	109400
Country	United States

Received	2025-05-12 02:59
Peer-Review Started	2025-05-13 08:46
To Make the First Decision
Return for Revision	2025-05-23 11:27
Revised	2025-05-28 01:07
Second Decision	2025-07-10 02:46
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-07-10 03:14
Articles in Press	2025-07-10 03:14
Publication Fee Transferred	2025-05-29 18:22
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-09-10 08:06
Publish the Manuscript Online	2025-09-17 08:57

ISSN	2220-6124 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Urology & Nephrology
Manuscript Type	Case Report
Article Title	Avacopan in the treatment of relapsing polychondritis with myeloperoxidase-antineutrophil cytoplasmic antibody associated vasculitis: A case report
Manuscript Source	Unsolicited Manuscript
All Author List	Jack Tang Nguyen and Manish Anand
ORCID	Author(s) ORCID Number Jack Tang Nguyen http://orcid.org/0009-0006-6033-299X
Funding Agency and Grant Number
Corresponding Author	Jack Tang Nguyen, Doctorate Student, College of Medicine, University of Cincinnati, 3230 Eden Ave, Cincinnati, OH 45220, United States. nguyenjack91801@gmail.com
Key Words	Antineutrophil cytoplasmic antibody; Polychondritis; Vasculitis; Myeloperoxidase-antineutrophil cytoplasmic antibody; Case report
Core Tip	This case report presents a rare overlap of relapsing polychondritis and myeloperoxidase anti-neutrophil cytoplasmic antibody associated vasculitis, complicated by severe acute kidney injury. The patient demonstrated sustained renal improvement following treatment with Avacopan, a complement 5a receptor antagonist, after intolerance to rituximab. This case highlights the potential role of Avacopan in preserving renal function and achieving disease control in complex autoimmune syndromes, especially when conventional immunosuppressive regimens are contraindicated or poorly tolerated.
Publish Date	2025-09-17 08:57
Citation	<p>Nguyen JT, Anand M. Avacopan in the treatment of relapsing polychondritis with myeloperoxidase-antineutrophil cytoplasmic antibody associated vasculitis: A case report. <i>World J Nephrol</i> 2025; 14(3): 109400</p>
URL	https://www.wjgnet.com/2220-6124/full/v14/i3/109400.htm
DOI	https://dx.doi.org/10.5527/wjn.v14.i3.109400

Full Article (PDF)	WJN-14-109400-with-cover.pdf
CARE Checklist–2016	109400-CARE-Checklist-2016.pdf
Manuscript File	109400_Auto_Edited_023303.docx
Answering Reviewers	109400-answering-reviewers.pdf
Audio Core Tip	109400-audio.m4a
Conflict-of-Interest Disclosure Form	109400-conflict-of-interest-statement.pdf
Copyright License Agreement	109400-copyright-assignment.pdf
Signed Consent for Treatment Form(s) or Document(s)	109400-informed-consent-statement.pdf
Peer-review Report	109400-peer-reviews.pdf
Scientific Misconduct Check	109400-scientific-misconduct-check.png
Scientific Editor Work List	109400-scientific-editor-work-list.pdf
CrossCheck Report	109400-crosscheck-report.pdf