Publication Name	World Journal of Gastroenterology
Manuscript ID	10941
Country	Japan

Received	2014-04-27 13:48
Peer-Review Started	2014-04-27 14:21
To Make the First Decision	2014-05-13 19:53
Return for Revision	2014-05-21 08:25
Revised
Second Decision	2014-07-11 17:02
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-07-11 17:15
Articles in Press	2014-07-11 17:34
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-12-26 11:36
Publish the Manuscript Online	2015-01-18 16:09

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Thrombomodulin in the management of acute cholangitis-induced disseminated intravascular coagulation
Manuscript Source	Unsolicited Manuscript
All Author List	Keigo Suetani, Chiaki Okuse, Kazunari Nakahara, Yosuke Michikawa, Yohei Noguchi, Midori Suzuki, Ryo Morita, Nozomi Sato, Masaki Kato and Fumio Itoh
Funding Agency and Grant Number
Corresponding Author	Kazunari Nakahara, PhD, Department of Gastroenterology and Hepatology, St. Marianna University, School of Medicine, 2-16-1 Sugao, Miyamae-ku, Kawasaki 216-8511, Japan. nakahara@marianna-u.ac.jp
Key Words	Disseminated intravascular coagulation; Acute cholangitis; Thrombomodulin; Biliary drainage; Anticoagulant therapy
Core Tip	To evaluate the need for thrombomodulin (rTM) in the management of acute cholangitis (AC)-induced disseminated intravascular coagulation (DIC), we retrospectively compared patients treated with rTM (rTM group) and without rTM (control group). DIC resolution rates were higher in the rTM group (P < 0.01). Multivariate analysis identified only the absence of biliary drainage as significantly associated with persistent DIC (P < 0.01), while there was a trend towards an association between persistent DIC and a lack of rTM (P = 0.08). Therefore, the add-on effects of rTM are anticipated in the treatment of AC-induced DIC, although biliary drainage remains crucial.
Publish Date	2015-01-18 16:09
Citation	Suetani K, Okuse C, Nakahara K, Michikawa Y, Noguchi Y, Suzuki M, Morita R, Sato N, Kato M, Itoh F. Thrombomodulin in the management of acute cholangitis-induced disseminated intravascular coagulation. World J Gastroenterol 2015; 21(2): 533-540
URL	http://www.wjgnet.com/1007-9327/full/v21/i2/533.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i2.533

Full Article (PDF)	WJG-21-533.pdf
Full Article (Word)	WJG-21-533.doc
Manuscript File	10941-Review.doc
Answering Reviewers	10941-Answering reviewers.pdf
Copyright License Agreement	10941-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	10941-Language certificate.pdf
Peer-review Report	10941-Peer review.pdf
Scientific Misconduct Check	10941-CrossCheck.jpg
Scientific Editor Work List	10941-Scientific editor work list.pdf