| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Case Report |
| Article Title |
Bone marrow metastasis of gastric signet ring cell carcinoma complicated by thrombotic microangiopathy: A case report
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Wei Sun, Xiao-Ci Chen, Han Wang, Wei-Yu Chang, Yun He, Zeng-Hua Lin, Hui Jia, Xiao-Mei Zhang and Hong Liu |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the Research Project for Clinical Research on Precision Diagnosis and Innovative Treatment of Bone Marrow Failure |
2024YFC2510500 |
| Jiangsu Provincial Traditional Chinese Medicine Science and Technology Development Plan |
YB2020102 |
| Nantong Municipal Health Commission Research Project |
QN2023007 |
|
| Corresponding Author |
Hong Liu, Chief Physician, MD, PhD, Professor, Department of Hematology, Affiliated Hospital of Nantong University, 688 Qingnian East Road, Nantong City, Nantong 226001, Jiangsu Province, China. hongliu63@126.com |
| Key Words |
Gastric signet ring cell carcinoma; Thrombotic microangiopathy; Bone marrow metastasis; Bone marrow necrosis; Bone marrow fibrosis; Diagnosis and treatment; Case report |
| Core Tip |
Thrombotic microangiopathy (TMA), characterized by microangiopathic hemolytic anemia and multi-organ failure, is a rare and underrecognized complication of malignancies. This report highlights a fatal case of gastric signet-ring cell carcinoma with bone marrow metastasis and TMA, diagnosed 15 months post-gastrectomy. TMA may precede cancer recurrence and is frequently misdiagnosed due to overlapping symptoms. Supportive therapies achieved transient remission, but discontinuation led to fatal progression. Currently, the disease is managed through plasma exchange, but evidence supporting efficacy of this treatment is lacking. This case demonstrates that TMA may be a potential early marker of aggressive malignancies and emphasizes the urgent need to clarify its pathogenesis and optimize treatment strategies for cancer-associated TMA. |
| Publish Date |
2025-08-14 05:49 |
| Citation |
<p>Sun W, Chen XC, Wang H, Chang WY, He Y, Lin ZH, Jia H, Zhang XM, Liu H. Bone marrow metastasis of gastric signet ring cell carcinoma complicated by thrombotic microangiopathy: A case report. <i>World J Gastrointest Oncol</i> 2025; 17(8): 109424</p> |
| URL |
https://www.wjgnet.com/1948-5204/full/v17/i8/109424.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v17.i8.109424 |
