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Articles Published Processes
9/26/2025 8:19:42 AM | Browse: 121 | Download: 0
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Received |
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2025-05-12 11:26 |
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Peer-Review Started |
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2025-05-21 09:11 |
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To Make the First Decision |
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Return for Revision |
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2025-06-18 02:01 |
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Revised |
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2025-06-27 14:10 |
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Second Decision |
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2025-08-01 02:46 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-08-08 06:18 |
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Articles in Press |
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2025-08-08 06:18 |
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Publication Fee Transferred |
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2025-07-02 14:05 |
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Edit the Manuscript by Language Editor |
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2025-08-12 21:20 |
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Typeset the Manuscript |
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2025-09-15 00:57 |
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Publish the Manuscript Online |
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2025-09-26 08:19 |
| ISSN |
2220-3206 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Psychiatry |
| Manuscript Type |
Basic Study |
| Article Title |
Brain region and cell specificity of B4GALT6 in depressive-like behavior mice: A pilot study
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Shi-Na Zhang, Di Luan, Bo-Yang Sheng, Bing Xie and Le Xiao |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Hunan Provincial Natural Science Foundation of China |
2025JJ80473 |
| Hunan Provincial Natural Science Foundation of China |
2025JJ80484 |
| the Institute of Hospital Management, National Health Commission of China, Major Project |
SZ2024HL021 |
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| Corresponding Author |
Le Xiao, Chief Physician, Rehabilitation Medicine Department, The First Hospital of Changsha, (The Affiliated Changsha Hospital of Xiangya School of Medicine, Central South University), 311 Yingpan Road, Kaifu District, Changsha 410005, Hunan Province, China. teacherfnr@163.com |
| Key Words |
Major depressive disorder; rs372369000; B4GALT6; Potential therapeutic target; Gene expression |
| Core Tip |
Major depressive disorder (MDD) poses a serious threat to human life. The SNP rs372369000 located within the β-1,4-galactosyltransferase 6 (B4GALT6) gene is a risk locus for MDD. However, the pathological mechanism of B4GALT6 in the brain concerning MDD remain unclear. We developed an inflammation-associated depression model and examined the brain distributions and level alterations of B4GALT6-like immunoreactivity. Our findings indicate the expression of B4GALT6-like immunoreactivity increased in the hippocampus, PrL, and the visual cortex V1 region of these mice. This elevation varied across different brain subregions and cell types. B4GALT6 may emerge as a potential therapeutic target for MDD. |
| Publish Date |
2025-09-26 08:19 |
| Citation |
<p>Zhang SN, Luan D, Sheng BY, Xie B, Xiao L. Brain region and cell specificity of B4GALT6 in depressive-like behavior mice: A pilot study. <i>World J Psychiatry</i> 2025; 15(10): 109425</p> |
| URL |
https://www.wjgnet.com/2220-3206/full/v15/i10/109425.htm |
| DOI |
https://dx.doi.org/10.5498/wjp.v15.i10.109425 |
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