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9/25/2025 11:24:00 AM | Browse: 72 | Download: 47
Publication Name World Journal of Hepatology
Manuscript ID 109429
Country China
Received
2025-05-12 03:37
Peer-Review Started
2025-05-12 08:49
First Decision by Editorial Office Director
2025-05-29 08:53
Return for Revision
2025-05-29 08:53
Revised
2025-06-06 08:05
Publication Fee Transferred
Second Decision by Editor
2025-07-31 02:40
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2025-07-31 08:31
Articles in Press
2025-07-31 08:31
Edit the Manuscript by Language Editor
Typeset the Manuscript
2025-09-12 08:30
Publish the Manuscript Online
2025-09-25 11:24
ISSN 1948-5182 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Letter to the Editor
Article Title Interleukin-36 subfamily cytokines in liver diseases
Manuscript Source Unsolicited Manuscript
All Author List Zhe-Kun Xiong, Si-Min Gu and Yi-Yuan Zheng
ORCID
Author(s) ORCID Number
Zhe-Kun Xiong http://orcid.org/0000-0003-3307-6573
Si-Min Gu http://orcid.org/0009-0001-0409-4708
Yi-Yuan Zheng http://orcid.org/0000-0001-9487-3766
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China 82104549
Corresponding Author Yi-Yuan Zheng, Department of Gastroenterology, Shanghai Municipal Hospital of Traditional Chinese Medicine, No. 274 Zhijiang Middle Road, Shanghai 200071, China. iceroser@126.com
Key Words Interleukin-36; Inflammation; Macrophages; T cells; Liver cirrhosis; Metabolic dysfunction-associated liver disease; Gut microbiota
Core Tip This letter discusses the important role of the interleukin-36 (IL-36) subfamily in the pathogenesis of liver diseases, particularly in modulating immune responses and promoting inflammation. Although considerable knowledge gaps remain regarding the precise mechanisms through which IL-36 cytokines contribute to liver damage, emerging evidence suggests that the targeting of IL-36 signaling may present novel therapeutic avenues for the management of chronic liver diseases. Further research is essential to investigate the potential of IL-36 as both a biomarker and a therapeutic target within clinical contexts.
Publish Date 2025-09-25 11:24
Citation

Xiong ZK, Gu SM, Zheng YY. Interleukin-36 subfamily cytokines in liver diseases. World J Hepatol 2025; 17(9): 109429

URL https://www.wjgnet.com/1948-5182/full/v17/i9/109429.htm
DOI https://dx.doi.org/10.4254/wjh.v17.i9.109429
Full Article (PDF) WJH-17-109429-with-cover.pdf
Manuscript File 109429_Auto_Edited_031356.docx
Answering Reviewers 109429-answering-reviewers.pdf
Audio Core Tip 109429-audio.mp3
Conflict-of-Interest Disclosure Form 109429-conflict-of-interest-statement.pdf
Copyright License Agreement 109429-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate 109429-non-native-speakers.pdf
Peer-review Report 109429-peer-reviews.pdf
Scientific Misconduct Check 109429-scientific-misconduct-check.png
Scientific Editor Work List 109429-scientific-editor-work-list.pdf
CrossCheck Report 109429-crosscheck-report.pdf