Publication Name	World Journal of Gastroenterology
Manuscript ID	109465
Country	South Korea

Received	2025-05-14 02:22
Peer-Review Started	2025-05-14 02:23
To Make the First Decision
Return for Revision	2025-06-04 02:27
Revised	2025-06-17 11:41
Second Decision	2025-07-21 02:57
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-07-21 06:05
Articles in Press	2025-07-21 06:05
Publication Fee Transferred	2025-06-18 04:44
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-08-04 00:37
Publish the Manuscript Online	2025-08-07 06:39

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Pathology
Manuscript Type	Retrospective Study
Article Title	Prognostic value of signet-ring cell carcinoma proportion in undifferentiated gastric cancer: Implications for endoscopic treatment decisions
Manuscript Source	Unsolicited Manuscript
All Author List	Chanyoung Kim, Hye Seung Lee, Hee Young Na, Hyun Jung Kwon, Ji Ae Lee, Yun-Suhk Suh, So Hyun Kang, Hyung-Ho Kim, Sang-Hoon Ahn and Hyeon Jeong Oh
ORCID	Author(s) ORCID Number Chanyoung Kim http://orcid.org/0009-0009-7333-7724 Hye Seung Lee http://orcid.org/0000-0002-1667-7986 Hee Young Na http://orcid.org/0000-0002-2464-0665 Hyun Jung Kwon http://orcid.org/0000-0001-8822-7899 Ji Ae Lee http://orcid.org/0000-0003-1493-6208 Yun-Suhk Suh http://orcid.org/0000-0003-3319-8482 So Hyun Kang http://orcid.org/0000-0002-8248-9043 Hyung-Ho Kim http://orcid.org/0000-0002-8916-0048 Sang-Hoon Ahn http://orcid.org/0000-0001-8827-3625 Hyeon Jeong Oh http://orcid.org/0000-0002-9998-3988
Funding Agency and Grant Number
Corresponding Author	Hyeon Jeong Oh, MD, PhD, Department of Pathology, Seoul National University Bundang Hospital, 82, Gumi-ro 173 Beon-gil, Seongnam-si 13620, Gyeonggi-do, South Korea. biohjoh212@gmail.com
Key Words	Gastric cancer; Signet-ring cell carcinoma; Poorly cohesive carcinoma; Prognosis; Endoscopic submucosal dissection
Core Tip	A higher proportion of signet-ring cell carcinoma (SRCC) in poorly cohesive gastric carcinoma indicates less aggressive tumor behavior, reflected by smaller size, lower stage, and reduced lymphovascular invasion. Patients with ≥ 90% SRCC show excellent recurrence-free and overall survival. In early gastric cancer, lower SRCC proportions are linked to ulceration, larger size, and deeper invasion. These findings highlight the prognostic value of SRCC proportion and its potential to guide therapeutic strategies, including endoscopic resection.
Publish Date	2025-08-07 06:39
Citation	<p>Kim C, Lee HS, Na HY, Kwon HJ, Lee JA, Suh YS, Kang SH, Kim HH, Ahn SH, Oh HJ. Prognostic value of signet-ring cell carcinoma proportion in undifferentiated gastric cancer: Implications for endoscopic treatment decisions. <i>World J Gastroenterol</i> 2025; 31(30): 109465</p>
URL	https://www.wjgnet.com/1007-9327/full/v31/i30/109465.htm
DOI	https://dx.doi.org/10.3748/wjg.v31.i30.109465

Full Article (PDF)	WJG-31-109465-with-cover.pdf
Manuscript File	109465_Auto_Edited_064810.docx
Answering Reviewers	109465-answering-reviewers.pdf
Audio Core Tip	109465-audio.m4a
Biostatistics Review Certificate	109465-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	109465-conflict-of-interest-statement.pdf
Copyright License Agreement	109465-copyright-assignment.pdf
Signed Informed Consent Form(s) or Document(s)	109465-informed-consent-statement.pdf
Institutional Review Board Approval Form or Document	109465-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate	109465-non-native-speakers.pdf
Supplementary Material	109465-supplementary-material.pdf
Peer-review Report	109465-peer-reviews.pdf
Scientific Misconduct Check	109465-scientific-misconduct-check.png
Scientific Editor Work List	109465-scientific-editor-work-list.pdf
CrossCheck Report	109465-crosscheck-report.pdf