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Articles Published Processes
11/14/2025 12:56:23 AM | Browse: 10 | Download: 75
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Received |
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2025-06-24 08:36 |
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Peer-Review Started |
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2025-06-24 08:36 |
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First Decision by Editorial Office Director |
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2025-07-15 06:30 |
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Return for Revision |
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2025-07-15 06:30 |
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Revised |
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2025-08-12 08:07 |
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Publication Fee Transferred |
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2025-08-20 08:44 |
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Second Decision by Editor |
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2025-10-20 02:48 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-10-20 07:39 |
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Articles in Press |
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2025-10-20 07:39 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-11-04 08:41 |
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Publish the Manuscript Online |
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2025-11-14 00:56 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Myc-associated zinc finger protein drives colorectal cancer metastasis through activating ubiquitin like with ring finger protein one
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Hui-Qin Mao, Fang-Cao Yu, Dan-Qiong Hu and Li-Jing Zhang |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Hangzhou Medical and Health Science and Technology Plan |
B20210014 |
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| Corresponding Author |
Hui-Qin Mao, Department of Ultrasonography, The Third People’s Hospital of Yuhang District, No. 8 Yangshanwan Road, Pingyao Town, Yuhang District, Hangzhou 311115, Zhejiang Province, China. 13968523585@163.com |
| Key Words |
Colorectal cancer metastasis; Myc-associated zinc finger protein; Ubiquitin-like with PHD and RING finger domains 1; Esophageal cancer-related gene 4; DNA methylation |
| Core Tip |
This study elucidated the oncogenic role of Myc-associated zinc finger protein (MAZ) in colorectal cancer (CRC), demonstrating its ability to promote cancer cell migration, invasion, and epithelial-mesenchymal transition by modulating the ubiquitin-like with PHD and RING finger domains 1-esophageal cancer-related gene 4 signaling pathway. MAZ was up-regulated in CRC cell species, and inhibition of its expression significantly inhibited cell invasion, invasion, epithelial-mesenchymal transition and tumor metastasis. Dual-luciferase reporter assay, chromatin immunoprecipitation quantitative polymerase chain reaction and methylation-specific polymerase chain reaction further validated the interaction of the MAZ-ubiquitin-like with PHD and RING finger domains 1-esophageal cancer-related gene 4 axis, providing convincing evidence for MAZ as a potential therapeutic target for CRC. |
| Publish Date |
2025-11-14 00:56 |
| Citation |
Mao HQ, Yu FC, Hu DQ, Zhang LJ. Myc-associated zinc finger protein drives colorectal cancer metastasis through activating ubiquitin like with ring finger protein one. World J Gastrointest Oncol 2025; 17(11): 109481 |
| URL |
https://www.wjgnet.com/1948-5204/full/v17/i11/109481.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v17.i11.109481 |
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