Publication Name	World Journal of Gastroenterology
Manuscript ID	109486
Country	China

Received	2025-05-16 07:49
Peer-Review Started	2025-05-16 07:49
To Make the First Decision
Return for Revision	2025-06-04 02:32
Revised	2025-06-26 14:58
Second Decision	2025-09-01 02:41
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-09-01 06:49
Articles in Press	2025-09-01 06:49
Publication Fee Transferred	2025-06-27 14:31
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-09-28 02:19
Publish the Manuscript Online	2025-10-14 07:41

ISSN	1007-9327 (print) and 2219-2840 (online)
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Rutaecarpine targets F-box and WD repeat domain containing 11 to inhibit inflammatory infiltration and alleviate acute pancreatitis
Manuscript Source	Unsolicited Manuscript
All Author List	Yan Jia, Yu-Xin Shi, Huan Gu, Ya Liu, Jie Peng and Lu Yan
ORCID	Author(s) ORCID Number Huan Gu http://orcid.org/0000-0001-6711-8378 Jie Peng http://orcid.org/0000-0002-6914-8260 Lu Yan http://orcid.org/0000-0002-7394-1106
Funding Agency and Grant Number	Funding Agency Grant Number Hunan Provincial Natural Science Foundation of China 2022JJ40836 Key Project of Research and Development Plan of Hunan Province 2023DK2002 Postdoctoral Fellowship Program of China Postdoctoral Science Foundation GZC20242045
Corresponding Author	Lu Yan, MD, Department of Gastroenterology, Xiangya Hospital, Central South University, No. 87 Xiangya Road, Changsha 410008, Hunan Province, China. yanluxy@csu.edu.cn
Key Words	Acute pancreatitis; Rutaecarpine; Enhancer of zeste homolog 2; H3 methylation; F-box and WD repeat domain containing 11
Core Tip	Rutaecarpine (Rut) is a major bioactive compound with a broad spectrum of pharmacological properties. Our previous study demonstrated that Rut significantly alleviated pancreatic inflammation and necrosis in acute pancreatitis (AP) rat models, primarily through a calcitonin gene-related peptide-dependent manner involving the suppression of inflammatory signaling pathways. However, given the multifactorial pathogenesis of AP and Rut’s inherent polypharmacological properties, the precise molecular mechanisms responsible for its protective effects warrant further investigation. Thus, based on the original research, this study uncovers a previously unrecognized mechanism of Rut (enhancer of zeste homolog 2-dependent F-box and WD repeat domain containing 11 suppression) and provides evidence that traditional Chinese medicine can target epigenetic reprogramming in AP.
Publish Date	2025-10-14 07:41
Citation	<p>Jia Y, Shi YX, Gu H, Liu Y, Peng J, Yan L. Rutaecarpine targets F-box and WD repeat domain containing 11 to inhibit inflammatory infiltration and alleviate acute pancreatitis. <i>World J Gastroenterol</i> 2025; 31(38): 109486</p>
URL	https://www.wjgnet.com/1007-9327/full/v31/i38/109486.htm
DOI	https://dx.doi.org/10.3748/wjg.v31.i38.109486

Full Article (PDF)	WJG-31-109486-with-cover.pdf
The ARRIVE Guidelines	109486-The-ARRIVE-Guidelines.pdf
Manuscript File	109486_Auto_Edited_083722.docx
Answering Reviewers	109486-answering-reviewers.pdf
Audio Core Tip	109486-audio.mp3
Biostatistics Review Certificate	109486-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	109486-conflict-of-interest-statement.pdf
Copyright License Agreement	109486-copyright-assignment.pdf
Institutional Animal Care and Use Committee Approval Form or Document	109486-institutional-animal-care-and-use-committee-statement.pdf
Non-Native Speakers of English Editing Certificate	109486-non-native-speakers.pdf
Peer-review Report	109486-peer-reviews.pdf
Scientific Misconduct Check	109486-scientific-misconduct-check.png
Scientific Editor Work List	109486-scientific-editor-work-list.pdf
CrossCheck Report	109486-crosscheck-report.pdf