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Articles Published Processes
8/14/2025 5:49:41 AM | Browse: 12 | Download: 28
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Received |
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2025-05-13 05:05 |
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Peer-Review Started |
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2025-05-13 05:06 |
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To Make the First Decision |
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Return for Revision |
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2025-05-22 10:13 |
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Revised |
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2025-06-02 04:50 |
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Second Decision |
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2025-07-16 02:36 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-07-16 09:45 |
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Articles in Press |
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2025-07-16 09:45 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-08-01 01:30 |
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Publish the Manuscript Online |
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2025-08-14 05:49 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
Unmasking immune checkpoint resistance in esophageal squamous cell carcinoma: Insights into the tumor microenvironment and biomarker landscape
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Zhe Wang, Rui-Ying Zhang, Yi-Fan Xu, Bing-Tong Yue, Jia-Yi Zhang and Feng Wang |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Feng Wang, MD, PhD, Professor, Senior Researcher, Senior Scientist, Oncology, The First Affiliated Hospital of Zhengzhou University, No.50 Eastern Jianshe Road, Zhengzhou 450052, Henan Province, China. zzuwangfeng@zzu.edu.cn |
| Key Words |
Esophageal squamous cell carcinoma; Immunotherapy resistance; Tumor microenvironment; Immune checkpoint blockade; Biomarkers |
| Core Tip |
Esophageal squamous cell carcinoma (ESCC) poses significant clinical challenges due to its aggressive progression and poor survival outcomes. While immunotherapy offers promise, resistance—both primary and acquired—remains a major hurdle, limiting its efficacy. This review explores the mechanisms of immunotherapy resistance in ESCC, including immunosuppressive cells, inhibitory cytokines, and molecular alterations in programmed death 1/programmed death-ligand 1 signaling. We also examine emerging strategies to overcome resistance, such as combination therapies and tumor microenvironment remodeling, emphasizing the need for predictive biomarkers to improve patient outcomes. |
| Publish Date |
2025-08-14 05:49 |
| Citation |
<p>Wang Z, Zhang RY, Xu YF, Yue BT, Zhang JY, Wang F. Unmasking immune checkpoint resistance in esophageal squamous cell carcinoma: Insights into the tumor microenvironment and biomarker landscape. <i>World J Gastrointest Oncol</i> 2025; 17(8): 109489</p> |
| URL |
https://www.wjgnet.com/1948-5204/full/v17/i8/109489.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v17.i8.109489 |
© 2004-2025 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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