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10/14/2025 7:42:39 AM | Browse: 60 | Download: 151
Publication Name World Journal of Gastrointestinal Oncology
Manuscript ID 109503
Country China
Received
2025-06-05 09:19
Peer-Review Started
2025-06-05 09:19
First Decision by Editorial Office Director
2025-07-08 06:38
Return for Revision
2025-07-08 06:38
Revised
2025-07-18 09:26
Publication Fee Transferred
2025-07-22 09:11
Second Decision by Editor
2025-09-16 02:37
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2025-09-16 07:31
Articles in Press
2025-09-16 07:31
Edit the Manuscript by Language Editor
Typeset the Manuscript
2025-10-06 14:15
Publish the Manuscript Online
2025-10-14 07:42
ISSN 1948-5204 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Minireviews
Article Title Bidirectional regulation of the gut microbiome-immune axis in the immune microenvironment of colorectal cancer and targeted interventions
Manuscript Source Unsolicited Manuscript
All Author List Xin-Xin Liu, Bing Yang and Dong-Xin Tang
ORCID
Author(s) ORCID Number
Xin-Xin Liu http://orcid.org/0009-0006-0845-3110
Bing Yang http://orcid.org/0009-0005-3167-9954
Dong-Xin Tang http://orcid.org/0009-0006-3988-102X
Funding Agency and Grant Number
Corresponding Author Dong-Xin Tang, Chief Physician, MD, Professor, The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guizhou University of Traditional Chinese Medicine, No. 4 Dongqing Road, Huaxi District, Guiyang 550025, Guizhou Province, China. tdx7712@163.com
Key Words Microbiota-immune axis; Colorectal cancer; Immune microenvironment; Bidirectional regulation; Targeted intervention
Core Tip This review explores the bidirectional regulation of the microbiota-immune axis in the immune microenvironment of colorectal cancer (CRC). It discusses how gut microbiota influences immune responses and how the immune system modulates microbiota composition. Highlighting the complexity of these interactions, the review addresses unanswered questions about microbiota heterogeneity and its impact on therapeutic outcomes. It also examines targeted interventions and their potential to improve CRC treatment, offering new insights into both the basic mechanisms and clinical applications for effective therapy.
Publish Date 2025-10-14 07:42
Citation

Liu XX, Yang B, Tang DX. Bidirectional regulation of the gut microbiome-immune axis in the immune microenvironment of colorectal cancer and targeted interventions. World J Gastrointest Oncol 2025; 17(10): 109503

URL https://www.wjgnet.com/1948-5204/full/v17/i10/109503.htm
DOI https://dx.doi.org/10.4251/wjgo.v17.i10.109503
Full Article (PDF) WJGO-17-109503-with-cover.pdf
Manuscript File 109503_Auto_Edited_093858.docx
Answering Reviewers 109503-answering-reviewers.pdf
Audio Core Tip 109503-audio.m4a
Conflict-of-Interest Disclosure Form 109503-conflict-of-interest-statement.pdf
Copyright License Agreement 109503-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate 109503-non-native-speakers.pdf
Peer-review Report 109503-peer-reviews.pdf
Scientific Misconduct Check 109503-scientific-misconduct-check.png
Scientific Editor Work List 109503-scientific-editor-work-list.pdf
CrossCheck Report 109503-crosscheck-report.pdf