| ISSN |
1949-8454 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Minireviews |
| Article Title |
Macrophage-mediated metabolic dysregulation in the pancreas: Insights from obesity
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Ke-Ran Chen, Ze-Yu Chen, Fei-Yi Liu, Cong-Yi Xie, Jie Hu, Shuai-Yan Wang, Bin Xu and Tian-Cheng Xu |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China, Young Scientists Fund Project |
82305376 |
| Jiangsu Province Young Scientific and Technological Talents Support Project |
JSTJ-2024-380 |
| Young Talents Support Project of China Association of Acupuncture-Moxibustion |
2024-2026ZGZJXH-QNRC005 |
| 2025 Jiangsu Science and Technology Think Tank Program Project |
JSKX0125035 |
|
| Corresponding Author |
Tian-Cheng Xu, Academic Editor, CEO, Chairman, Founder, Head, MD, PhD, Key Laboratory of Acupuncture and Medicine Research of Ministry of Education, Nanjing University of Chinese Medicine, No. 138 Xianlin Avenue, Qixia District, Nanjing 210023, Jiangsu Province, China. xtc@njucm.edu.cn |
| Key Words |
Obesity; Pancreas; Macrophages; Metabolic dysfunction; Inflammation response |
| Core Tip |
Obesity contributes to the polarisation of pancreatic macrophages towards pro-inflammatory Macrophage, pro-inflammatory phenotype type through chronic inflammation, releasing factors such as C-C motif ligand 2 and transforming growth factor beta that impair β-cell function and trigger fibrosis. Macrophage metabolites and their interactions with vesicular cells have been identified as key mechanisms of metabolic disorders. Targeted regulation of macrophage polarisation such as the PPAR-γ pathway shows therapeutic potential. Future studies need to focus on macrophage subpopulation heterogeneity to develop precise therapeutic strategies. |
| Publish Date |
2025-12-04 06:40 |
| Citation |
Chen KR, Chen ZY, Liu FY, Xie CY, Hu J, Wang SY, Xu B, Xu TC. Macrophage-mediated metabolic dysregulation in the pancreas: Insights from obesity. World J Biol Chem 2025; 16(4): 109509 |
| URL |
https://www.wjgnet.com/1949-8454/full/v16/i4/109509.htm |
| DOI |
https://dx.doi.org/10.4331/wjbc.v16.i4.109509 |
