| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Pharmacology & Pharmacy |
| Manuscript Type |
Basic Study |
| Article Title |
Ultrasound imaging-guided protocol for monitoring tumor growth in orthotopic rat model of hepatocellular carcinoma
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Aswathy R Devan, Sithara Manakkaparambil Sasidharan, Kannoth Panicker Sreekumar, Ayalur Kodakara Kochugovindan Unni, Sabitha Mangalathillam, Abna Ansar, Ashok R Unni and Lekshmi R Nath |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Amrita Vishwa Vidyapeetham Seed Grant |
K-PHAR-24-722 |
| DST INSPIRE Fellowship |
IF190226 |
|
| Corresponding Author |
Lekshmi R Nath, Associate Professor, PhD, Department of Pharmacognosy, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, AIMS Health Science Campus, Ponekkara PO, Kochi 682041, Kerala, India. lekshmirnath@aims.amrita.edu |
| Key Words |
Hepatocellular carcinoma; Syngeneic N1S1 orthotopic model; Ultrasound imaging; Tumor growth monitoring; Therapeutic response; Cost-effective imaging tool; Inter-observer reproducibility; Receiver Operating Characteristics analysis |
| Core Tip |
Orthotopic rat tumor models are valuable for replicating human tumor microenvironments, yet tumor regression complicates consistent growth assessment, underscoring the need for reliable imaging modalities. While advanced techniques like magnetic resonance imaging and micro-computed tomography deliver high-resolution data, their expense, effects and demands limit routine implementation. We present an ultrasound (US) imaging protocol that achieves accuracy and sensitivity for regular tumor growth monitoring. Our results demonstrate US’s potential for early detection of orthotopic liver tumors and robust evaluation of antitumor drug efficacy, offering a cost-effective, accessible alternative strategy in preclinical research. |
| Publish Date |
2025-10-27 10:57 |
| Citation |
<p>Devan AR, Sasidharan SM, Sreekumar KP, Unni AKK, Mangalathillam S, Ansar A, Unni AR, Nath LR. Ultrasound imaging-guided protocol for monitoring tumor growth in orthotopic rat model of hepatocellular carcinoma. <i>World J Hepatol</i> 2025; 17(10): 109517</p> |
| URL |
https://www.wjgnet.com/1948-5182/full/v17/i10/109517.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v17.i10.109517 |
