| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cardiac & Cardiovascular Systems |
| Manuscript Type |
Basic Study |
| Article Title |
Right ventricular dysfunctions in type 1 diabetic mice: A longitudinal study
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Jian-Jian Yu, Jian-Ge Han, Yi Tan, Jian-Xiang Xu, Amanda LeBlanc, Bradley B Keller, Jiapeng Huang and Lu Cai |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| University of Louisville - China Pediatric Research Exchange Program |
|
| University of Louisville Executive Vice President for Research and Innovation Internal Grant |
|
| University of Louisville School of Medicine Basic Grant |
|
|
| Corresponding Author |
Lu Cai, MD, PhD, Professor, Department of Pediatrics, Pediatric Research Institute, University of Louisville School of Medicine, 570 South Preston Street, Baxter I, Louisville, KY 40202, United States. lu.cai@louisville.edu |
| Key Words |
Diabetic cardiomyopathy; Type 1 diabetes; Right ventricle; Left ventricle; Cardiac remodeling; Cardiac dysfunction |
| Core Tip |
Diabetic cardiomyopathy is one of diabetes-associated complications. However, the temporal relationship between right ventricle (RV) and left ventricle (LV) systolic/diastolic functions in diabetes has not been explored. Therefore, longitudinal RV and LV function changes were examined in transgenic OVE26, type 1 diabetes (T1D) mice and their wild‐type FVB mice over 30-week period. The development of early LV diastolic dysfunction, followed by LV systolic dysfunction and RV diastolic dysfunction at 30-weeks in T1D mice. Increased pulmonary acceleration time to pulmonary ejection time ratio and RV peak systolic pressure at 30-weeks suggested the development of mild pulmonary arterial hypertension in T1D mice. |
| Publish Date |
2025-10-15 09:03 |
| Citation |
<p>Yu JJ, Han JG, Tan Y, Xu JX, LeBlanc A, Keller BB, Huang J, Cai L. Right ventricular dysfunctions in type 1 diabetic mice: A longitudinal study. <i>World J Diabetes</i> 2025; 16(10): 109526</p> |
| URL |
https://www.wjgnet.com/1948-9358/full/v16/i10/109526.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v16.i10.109526 |
