| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Integrative & Complementary Medicine |
| Manuscript Type |
Basic Study |
| Article Title |
Nephroprotective mechanism of Kunkui Baoshen decoction: Targeting the HERC2/NCOA4-mediated autophagy-dependent ferroptosis pathway in diabetic kidney disease
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Si-Yuan Song, Chu-Chu Shan, Pei-Pei Zhou, Wei-Long Xu, Ying Tan, Xi-Qiao Zhou, Li-Ji Huang, Qian-Hua Yan and Jiang-Yi Yu |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
82205025 |
| National Natural Science Foundation of China |
82374355 |
| National Natural Science Foundation of China |
82174293 |
|
| Corresponding Author |
Jiang-Yi Yu, MD, Department of Endocrinology, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, No. 155 Hanzhong Road, Qinhuai District, Nanjing 210000, Jiangsu Province, China. 1401743118@qq.com |
| Key Words |
Ubiquitination; Ferroptosis; Diabetic kidney disease; Renal fibrosis; Kunkui Baoshen decoction |
| Core Tip |
Kunkui Baoshen decoction (KKBS), a traditional Chinese herbal formula, exerts renoprotective effects in DKD by inhibiting autophagy-dependent ferroptosis. Through integrated transcriptomic and metabolomic analyses, we identified the Homologous to E6-AP C-terminus and RCC1-like domain-containing E3 ubiquitin protein ligase/nuclear receptor coactivator 4 axis as a critical therapeutic target. KKBS enhances Homologous to E6-AP C-terminus and RCC1-like domain-containing E3 ubiquitin protein ligase-mediated K48-linked ubiquitination of nuclear receptor coactivator 4, promoting its degradation and thereby suppressing ferroptosis, renal inflammation, and fibrosis in high glucose-induced human kidney-2 cells and db/db mice. This research reveals a novel pathway through which KKBS regulates ferroptosis to prevent DKD progression. |
| Publish Date |
2025-10-15 09:03 |
| Citation |
<p>Song SY, Shan CC, Zhou PP, Xu WL, Tan Y, Zhou XQ, Huang LJ, Yan QH, Yu JY. Nephroprotective mechanism of Kunkui Baoshen decoction: Targeting the HERC2/NCOA4-mediated autophagy-dependent ferroptosis pathway in diabetic kidney disease. <i>World J Diabetes</i> 2025; 16(10): 109568</p> |
| URL |
https://www.wjgnet.com/1948-9358/full/v16/i10/109568.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v16.i10.109568 |
