| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Chemistry, Medicinal |
| Manuscript Type |
Basic Study |
| Article Title |
TSC22D1 promotes liver sinusoidal endothelial cell dysfunction and induces macrophage M1 polarization in non-alcoholic fatty liver disease
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Wei Ding, Xin-Qi Xu, Ling-Lin Wu, Qun Wang, Yi-Qin Wang, Wei-Wei Chen, Yu-Lin Tan, Yi-Bo Wang, Hua-Ji Jiang, Jun Dong, Yong-Min Yan and Xue-Zhong Xu |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Changzhou Science and Techology Program |
No. CJ20241048 |
| Changzhou High-Level Medical Talents Training Project |
No. 2022CZBJ105 |
| Development Foundation of the Affiliated Hospital of Xuzhou Medical University |
No. XYFC202304 |
| Development Foundation of the Affiliated Hospital of Xuzhou Medical University |
No. XYFM202307 |
| The Open Project of Jiangsu Provincial Key Laboratory of Laboratory Medicine |
No. JSKLM-Z-2024-002 |
|
| Corresponding Author |
Xue-Zhong Xu, Chief Physician, Department of General Surgery, Wujin Hospital Affiliated with Jiangsu University, No. 85 East Gehu Road, Changzhou 213162, Jiangsu Province, China. xxzdoctor@163.com |
| Key Words |
Liver sinusoidal endothelial cells; TSC22D1; Non-alcoholic fatty liver disease; Macrophage polarization; Tumor necrosis factor-like weak inducer of apoptosis |
| Core Tip |
This study reveals that TSC22D1 plays a pivotal role in the progression of non-alcoholic fatty liver disease (NAFLD) fibrosis by promoting liver sinusoidal endothelial cell (LSEC) dysfunction and macrophage M1 polarization via the tumor necrosis factor-like weak inducer of apoptosis/fibroblast growth factor-inducible 14 signaling pathway. Through single-cell transcriptomic analysis and experimental validation, the authors demonstrate that TSC22D1 drives endothelial-mesenchymal transition and microvascularization in LSECs, while also enhancing pro-inflammatory responses in macrophages. Targeting TSC22D1 with adeno-associated virus serotype 8-short hairpin RNA alleviates liver fibrosis and inflammation in vivo, suggesting TSC22D1 as a promising therapeutic target for NAFLD. These findings provide novel insights into the mechanisms linking endothelial dysfunction, inflammation, and fibrosis in NAFLD. |
| Publish Date |
2025-08-18 10:04 |
| Citation |
<p>Ding W, Xu XQ, Wu LL, Wang Q, Wang YQ, Chen WW, Tan YL, Wang YB, Jiang HJ, Dong J, Yan YM, Xu XZ. TSC22D1 promotes liver sinusoidal endothelial cell dysfunction and induces macrophage M1 polarization in non-alcoholic fatty liver disease. <i>World J Gastroenterol</i> 2025; 31(31): 109605</p> |
| URL |
https://www.wjgnet.com/1007-9327/full/v31/i31/109605.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v31.i31.109605 |
