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Articles Published Processes
11/27/2025 7:53:55 AM | Browse: 130 | Download: 193
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Received |
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2025-05-19 15:26 |
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Peer-Review Started |
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2025-05-21 00:11 |
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First Decision by Editorial Office Director |
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2025-06-05 09:30 |
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Return for Revision |
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2025-06-05 09:30 |
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Revised |
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2025-06-18 22:18 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-10-09 01:07 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-10-10 03:20 |
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Articles in Press |
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2025-10-10 03:20 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-11-18 00:55 |
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Publish the Manuscript Online |
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2025-11-27 07:53 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Critical Care Medicine |
| Manuscript Type |
Minireviews |
| Article Title |
Hypertransaminasemia in non-cirrhotic critically-ill patients
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Marco Fiore, Gianluigi Cosenza, Francesco Coppolino, Vincenzo Pota, Pasquale Sansone, Stephen Petrou and Maria C Pace |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Marco Fiore, Lecturer, MD, Professor, Department of Women, Child and General and Specialized Surgery, University of Campania “Luigi Vanvitelli”, Piazza Miraglia 2, Naples 80138, Campania, Italy. marco.fiore@hotmail.it |
| Key Words |
Critically ill patients; Drug-induced liver injury; Hypertransaminasemia; Hypoxic liver injury; Intensive care unit; Liver dysfunction; Parenteral nutrition-associated liver disease; Sepsis-associated liver dysfunction |
| Core Tip |
Hypertransaminasemia in non-cirrhotic intensive care unit patients is more often the biochemical echo of hypoperfusion, sepsis, drug toxicity or parenteral-nutrition cholestasis than a sign of primary hepatopathy. A structured, pattern-based algorithm - degree of aspartate aminotransferase/alanine aminotransferase rise, timing, haemodynamic milieu and medication exposure - enables rapid discrimination among hypoxic liver injury, drug-induced liver injury, sepsis-associated liver injury and parenteral nutrition-associated liver disease, guides targeted intervention and prevents futile diagnostics. Novel biomarkers such as glutamate dehydrogenase and microRNA-122 provide muscle-independent, early detection of hepatocellular injury and represent the next frontier for precision hepatology in critical care. |
| Publish Date |
2025-11-27 07:53 |
| Citation |
Fiore M, Cosenza G, Coppolino F, Pota V, Sansone P, Petrou S, Pace MC. Hypertransaminasemia in non-cirrhotic critically-ill patients. World J Hepatol 2025; 17(11): 109645 |
| URL |
https://www.wjgnet.com/1948-5182/full/v17/i11/109645.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v17.i11.109645 |
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