| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Case Control Study |
| Article Title |
Peripheral basophil activation: A hidden player in the immunopathogenesis of primary biliary cholangitis
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Huan-Qin Han, Jia-Min Bao, Wei Deng, Wei-Fang Guo, Yi-Fan Li, Wei-Qiang Zheng and Hua‐Feng Liu |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Guangdong Provincial Basic and Applied Basic Research Fund |
2021A1515011589 |
| Guangdong Medical University Clinical + Basic Science and Technology Innovation Special Program |
GDMULCJC2024004 |
|
| Corresponding Author |
Hua‐Feng Liu, Chief Physician, MD, PhD, Professor, Department of Nephrology, National Clinical Key Specialty Construction Program (2023), Institute of Nephrology, Guangdong Provincial Key Laboratory of Autophagy and Major Chronic Non-communicable Diseases, Key Laboratory of Prevention and Management of Chronic Kidney Disease of Zhanjiang City, Affiliated Hospital of Guangdong Medical University, No. 57 South Renmin Road, Zhanjiang 524001, Guangdong Province, China. liuhf@gdmu.edu.cn |
| Key Words |
Primary biliary cholangitis; Basophils; Immunopathogenesis; T helper 17 Cells; CD4+T lymphocytes |
| Core Tip |
Peripheral basophil counts and proportions were significantly elevated in patients with primary biliary cholangitis (PBC), with increased expression of the activation marker CD203c mean fluorescence intensity and intracellular interleukin (IL)-6. Concurrently, CD4+ T lymphocytes in patients with PBC showed markedly increased IL-17 expression. These findings suggest that activated basophils, through IL-6 upregulation, may promote T helper 17 cell proliferation and promote PBC pathogenesis. |
| Publish Date |
2025-08-27 09:21 |
| Citation |
<p>Han HQ, Bao JM, Deng W, Guo WF, Li YF, Zheng WQ, Liu H. Peripheral basophil activation: A hidden player in the immunopathogenesis of primary biliary cholangitis. <i>World J Hepatol</i> 2025; 17(8): 109685</p> |
| URL |
https://www.wjgnet.com/1948-5182/full/v17/i8/109685.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v17.i8.109685 |
