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Articles Published Processes
9/24/2025 3:48:38 AM | Browse: 16 | Download: 39
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Received |
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2025-05-19 03:54 |
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Peer-Review Started |
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2025-05-19 03:54 |
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To Make the First Decision |
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Return for Revision |
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2025-06-05 08:26 |
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Revised |
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2025-06-17 12:05 |
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Second Decision |
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2025-08-22 02:31 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-08-29 10:11 |
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Articles in Press |
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2025-08-29 10:11 |
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Publication Fee Transferred |
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2025-06-18 07:20 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-09-06 15:06 |
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Publish the Manuscript Online |
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2025-09-24 03:48 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, Research & Experimental |
| Manuscript Type |
Basic Study |
| Article Title |
Exploring the critical therapeutic window: Dose-frequency optimization of human umbilical cord mesenchymal stem cells for preclinical asthma treatment
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Qiong-Hua Chen, Jing-Yang Zheng, Yu-Qin Zhu, Jun-Yao Zhang, Chun-Yan Lin, Xue-E Zhuang, Jing Cheng and Xiao-Yi Huang |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Joint Innovation Project Funds of Huaqiao University |
2022YX001 |
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| Corresponding Author |
Qiong-Hua Chen, Deputy Director, /, The Graduate School of Fujian Medical University, No. 1 Xuefu North Road, Shangjie Town, Minhou County, Fuzhou 350122, Fujian Province, China. cqionghua283@163.com |
| Key Words |
Asthma; Human umbilical cord mesenchymal stem cells; Mouse; Dose; Frequency |
| Core Tip |
This study reports, human umbilical cord blood-derived mesenchymal stem cell (HUC-MSC) therapy shows potential for treating asthma with high purity. HUC-MSC has been demonstrated to modulate airway remodeling, enhance lung function, and inhibit the inflammatory response in acute ovalbumin-induced asthma model. This study provides appropriate reference dosages to explore the possible intervention of HUC-MSC further. A single dosage of 2 × 105 cells is optimal, while double treatments with 2 × 105 cells may be optimal in reducing airway obstruction, but not for modulating airway inflammation. |
| Publish Date |
2025-09-24 03:48 |
| Citation |
<p>Chen QH, Zheng JY, Zhu YQ, Zhang JY, Lin CY, Zhuang XE, Cheng J, Huang XY. Exploring the critical therapeutic window: Dose-frequency optimization of human umbilical cord mesenchymal stem cells for preclinical asthma treatment. <i>World J Stem Cells</i> 2025; 17(9): 109715</p> |
| URL |
https://www.wjgnet.com/1948-0210/full/v17/i9/109715.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v17.i9.109715 |
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