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9/23/2025 6:48:58 AM | Browse: 49 | Download: 27
Publication Name World Journal of Clinical Oncology
Manuscript ID 109717
Country United States
Received
2025-05-20 07:01
Peer-Review Started
2025-05-20 07:01
To Make the First Decision
Return for Revision
2025-06-23 01:42
Revised
2025-07-05 17:25
Second Decision
2025-08-01 02:38
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief
2025-08-01 13:20
Articles in Press
2025-08-01 13:20
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2025-09-01 06:00
Publish the Manuscript Online
2025-09-23 06:48
ISSN 2218-4333 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Oncology
Manuscript Type Letter to the Editor
Article Title Inflammation and detection: Rethinking the biomarker landscape in gastric cancer
Manuscript Source Invited Manuscript
All Author List Keykavous Parang and Koosha Paydary
ORCID
Author(s) ORCID Number
Keykavous Parang http://orcid.org/0000-0001-8600-0893
Koosha Paydary http://orcid.org/0000-0001-7459-1761
Funding Agency and Grant Number
Corresponding Author Keykavous Parang, Full Professor, PharmD, PhD, Professor, Tenured Professor, Center for Targeted Drug Delivery, Department of Biomedical and Pharmaceutical Sciences, School of Pharmacy, Chapman University, 9401 Jeronimo Road, Irvine, CA 92618, United States. parang@chapman.edu
Key Words Biomarker; Cytokine; Diagnosis; Gastric carcinoma; Inflammation; Pro-inflammatory
Core Tip This letter evaluates the diagnostic and therapeutic utility of key inflammatory cytokines, such as interleukin (IL)-1β, IL-6, IL-8, and interferon-gamma, in gastric carcinoma (GC). These molecules are discussed as both biomarkers and drivers of tumor progression and chemoresistance. The discussion situates these markers within a broader inflammatory biomarker landscape that includes IL-10, IL-11, IL-18, C-X-C motif ligand 9, and host genetic factors. The analysis supports the use of multiplex cytokine panels over single markers for GC detection and treatment stratification, and outlines future directions for clinical integration and biomarker-guided therapy.
Publish Date 2025-09-23 06:48
Citation <p>Parang K, Paydary K. Inflammation and detection: Rethinking the biomarker landscape in gastric cancer. <i>World J Clin Oncol</i> 2025; 16(9): 109717</p>
URL https://www.wjgnet.com/2218-4333/full/v16/i9/109717.htm
DOI https://dx.doi.org/10.5306/wjco.v16.i9.109717
Full Article (PDF) WJCO-16-109717-with-cover.pdf
Manuscript File 109717_Auto_Edited_015137.docx
Answering Reviewers 109717-answering-reviewers.pdf
Audio Core Tip 109717-audio.mp3
Conflict-of-Interest Disclosure Form 109717-conflict-of-interest-statement.pdf
Copyright License Agreement 109717-copyright-assignment.pdf
Peer-review Report 109717-peer-reviews.pdf
Scientific Misconduct Check 109717-scientific-misconduct-check.png
Scientific Editor Work List 109717-scientific-editor-work-list.pdf
CrossCheck Report 109717-crosscheck-report.pdf