| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Prospective Study |
| Article Title |
Serum homocysteine-based traffic light triage colonoscopy screening in colorectal cancer at-risk patients: A prospective cohort study
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Francisco Xavier Cano, José María Duque, Lucia Seoane, Miguel Puga-Tejada, Alejandra Espinoza de los Monteros, Pablo Bermeo, Eduardo Junquera, Daniel Pérez, Jimmy Martin-Delgado, Monica Santelli, Carla Pérez and Francisco Javier Pérez Rivera |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Francisco Xavier Cano, Doctorate Student, MD, Professor, Researcher, Instituto de Investigación e Innovación en Salud Integral, Universidad Católica de Santiago de Guayaquil, Av. Pdte. Carlos Julio Arosemena Tola, Guayaquil 090615, Guayas, Ecuador. francisco.cano@cu.ucsg.edu.ec |
| Key Words |
Homocysteine; Predictive value of a test; Colonoscopy; Colorectal cancer; Cancer screening |
| Core Tip |
In this study, we propose a traffic-light triage model based on serum homocysteine levels, sex, and age to prioritize colonoscopy after a positive fecal occult blood test. A green light (≤ 12 micromoles per liter in both sexes) indicates low risk and allows colonoscopy within three months. A yellow light (12-15 micromoles) in men suggests high-risk polyps and requires colonoscopy within one month. In women, the same range is already associated with adenocarcinoma and warrants immediate intervention. A red light (> 15 micromoles) in either sex is strongly associated with cancer and indicates the need for urgent colonoscopy. |
| Publish Date |
2025-09-05 06:36 |
| Citation |
<p>Cano FX, Duque JM, Seoane L, Puga-Tejada M, Espinoza de los Monteros A, Bermeo P, Junquera E, Pérez D, Martin-Delgado J, Santelli M, Pérez C, Pérez Rivera FJ. Serum homocysteine-based traffic light triage colonoscopy screening in colorectal cancer at-risk patients: A prospective cohort study. <i>World J Gastroenterol</i> 2025; 31(34): 109718</p> |
| URL |
https://www.wjgnet.com/1007-9327/full/v31/i34/109718.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v31.i34.109718 |
