Publication Name	World Journal of Gastroenterology
Manuscript ID	10978
Country	Germany

Received	2014-04-28 20:14
Peer-Review Started
To Make the First Decision
Return for Revision
Revised
Second Decision	2014-05-26 16:29
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-05-26 16:57
Articles in Press	2014-05-26 17:30
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-10-17 14:55
Publish the Manuscript Online	2014-10-29 19:34

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Topic Highlights
Article Title	SIBLINGs and SPARC families: Their emerging roles in pancreatic cancer
Manuscript Source	Invited Manuscript
All Author List	Ferda Kaleağasıoğlu and Martin R Berger
Funding Agency and Grant Number
Corresponding Author	Martin R Berger, Professor, Toxicology and Chemotherapy Unit, German Cancer Research Center, Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany. m.berger@dkfz-heidelberg.de
Key Words	Pancreatic cancer; Microenvironment; Signaling pathways; Osteopontin; Osteonectin; Hevin; Biomarker; Therapeutic targeting
Core Tip	In this article we review the evidence that the protein families “small integrin binding ligand N-linked glycoproteins” (SIBLINGs) and “secreted protein acidic and rich in cysteine” (SPARC) modulate functions like proliferation, differentiation, apoptosis, adhesion, migration, angiogenesis, wound repair, and regulation of extracellular matrix remodeling. Moreover they play significant roles throughout each stage of pancreatic cancer formation and progression. We discuss, with special reference to osteopontin and osteonectin, how SIBLING and SPARC proteins have attracted growing importance as diagnostic and prognostic tools and discuss their fascinating potential as therapeutic targets.
Publish Date	2014-10-29 19:34
Citation	Kaleağasıoğlu F, Berger MR. SIBLINGs and SPARC families: Their emerging roles in pancreatic cancer. World J Gastroenterol 2014; 20(40): 14747-14759
URL	http://www.wjgnet.com/1007-9327/full/v20/i40/14747.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i40.14747

Full Article (PDF)	WJG-20-14747.pdf
Full Article (Word)	WJG-20-14747.doc
Manuscript File	10978-Review.docx
Answering Reviewers	10978-Answering reviewers.pdf
Copyright License Agreement	10978-Copyright assignment.pdf
Peer-review Report	10978-Peer review(s).pdf
Scientific Misconduct Check	10978-CrossCheck.jpg
Scientific Editor Work List	10978-Scientific editor work list.pdf