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Articles Published Processes
10/15/2025 9:03:19 AM | Browse: 106 | Download: 387
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Received |
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2025-05-22 14:33 |
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Peer-Review Started |
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2025-05-26 00:13 |
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First Decision by Editorial Office Director |
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2025-06-07 02:07 |
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Return for Revision |
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2025-06-07 02:07 |
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Revised |
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2025-07-02 13:03 |
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Publication Fee Transferred |
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2025-07-06 13:41 |
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Second Decision by Editor |
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2025-08-11 02:13 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-08-25 11:15 |
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Articles in Press |
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2025-08-25 11:15 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-10-09 15:45 |
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Publish the Manuscript Online |
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2025-10-15 09:03 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Basic Study |
| Article Title |
Nicotinamide mononucleotide protects against diabetic nephropathy via IL-6/Rab5-mediated crosstalk between proximal tubular epithelial cells and podocytes
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Dong-Qing Zha, Ping Gao and Xiao-Yan Wu |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Hubei Provincial Natural Science Foundation |
2023AFB732 |
| Scientific Research Project of Hubei Provincial Health Commission |
WJ2023M053 |
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| Corresponding Author |
Xiao-Yan Wu, MD, Division of Nephrology, Zhongnan Hospital of Wuhan University, 169 Donghu Road, Wuhan 430070, Hubei Province, China. wuxiaoyan2k6@whu.edu.cn |
| Key Words |
Diabetic nephropathy; Podocyte injury; Interleukin-6; Rab5 signaling; Nicotinamide mononucleotide; Proximal tubular epithelial cell |
| Core Tip |
This study identified a novel mechanism in diabetic nephropathy (DN), in which high glucose-induced interleukin-6 (IL-6) secretion by proximal tubular epithelial cells activated Rab5 signaling in podocytes, followed by nephrin endocytosis and structural damage. Importantly, nicotinamide mononucleotide (NMN) effectively interrupted this pathogenic IL-6/Rab5-mediated intercellular crosstalk, thereby preserving podocyte integrity, reducing glomerular injury, and decreasing albuminuria. These findings highlight NMN as a potential therapeutic strategy for mitigation of DN by targeting IL-6/Rab5 signaling. |
| Publish Date |
2025-10-15 09:03 |
| Citation |
Zha DQ, Gao P, Wu XY. Nicotinamide mononucleotide protects against diabetic nephropathy via IL-6/Rab5-mediated crosstalk between proximal tubular epithelial cells and podocytes. World J Diabetes 2025; 16(10): 109782 |
| URL |
https://www.wjgnet.com/1948-9358/full/v16/i10/109782.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v16.i10.109782 |
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