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9/18/2025 9:55:58 AM | Browse: 719 | Download: 944
Publication Name World Journal of Gastroenterology
Manuscript ID 109808
Country South Korea
Received
2025-05-23 03:03
Peer-Review Started
2025-05-23 03:03
First Decision by Editorial Office Director
2025-06-11 07:24
Return for Revision
2025-06-11 07:24
Revised
2025-06-24 08:11
Publication Fee Transferred
Second Decision by Editor
2025-08-14 03:14
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2025-08-15 00:41
Articles in Press
2025-08-15 00:41
Edit the Manuscript by Language Editor
Typeset the Manuscript
2025-09-08 03:48
Publish the Manuscript Online
2025-09-18 09:55
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Basic Study
Article Title Comparative evaluation of three traditional herbal formulas on gastrointestinal motility in a mouse model of cold stress-induced dyspepsia
Manuscript Source Unsolicited Manuscript
All Author List Jing-Hua Wang, Song-Yi Han, Liangliang Wu, Uijeong Han, Si-Kyung Cho, Chan-Woong Park, Young-Won Chin, Mi Young Lim and Hojun Kim
ORCID
Author(s) ORCID Number
Jing-Hua Wang http://orcid.org/0000-0002-2034-7429
Hojun Kim http://orcid.org/0000-0003-1038-0142
Funding Agency and Grant Number
Funding Agency Grant Number
National Research Foundation of Korea No. 2022M3A9E4017033
Corresponding Author Hojun Kim, Division of Rehabilitation Medicine of Korean Medicine, Department of Oriental Rehabilitation Medicine, Dongguk University, Ilsan Hospital, 27 Dongguk-ro, Goyang 10326, South Korea. kimklar@dongguk.ac.kr
Key Words Non-alcoholic fatty liver disease; Alcoholic liver disease; Non-alcoholic steatohepatitis; Insulin resistance; Oxidative stress
Core Tip This study systematically compared the therapeutic effects of three classical herbal formulas (Pyeongwi-san, Shihosogan-tang, and Yijung-tang) in a mouse model of cold stress-induced dyspepsia. Among them, Pyeongwi-san was the most effective in restoring gastrointestinal motility, enhancing gastric acid secretion and upregulating digestive enzymes gene expression, and modulating serotonin, short-chain fatty acids, bile acid receptors, and glucagon-like peptide-1 signaling. These findings elucidate the mechanisms of Pyeongwi-san’s superior efficacy and strongly support its clinical application in treating cold-induced gastrointestinal dysfunction.
Publish Date 2025-09-18 09:55
Citation

Wang JH, Han SY, Wu L, Han U, Cho SK, Park CW, Chin YW, Lim MY, Kim H. Comparative evaluation of three traditional herbal formulas on gastrointestinal motility in a mouse model of cold stress-induced dyspepsia. World J Gastroenterol 2025; 31(35): 109808

URL https://www.wjgnet.com/1007-9327/full/v31/i35/109808.htm
DOI https://dx.doi.org/10.3748/wjg.v31.i35.109808
Full Article (PDF) WJG-31-109808-with-cover.pdf