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Articles Published Processes
10/14/2025 7:42:36 AM | Browse: 89 | Download: 175
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Received |
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2025-05-23 05:56 |
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Peer-Review Started |
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2025-05-23 05:56 |
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First Decision by Editorial Office Director |
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2025-05-29 08:50 |
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Return for Revision |
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2025-05-29 08:50 |
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Revised |
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2025-06-09 16:02 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-09-08 02:44 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-09-08 08:34 |
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Articles in Press |
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2025-09-08 08:34 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-09-25 01:33 |
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Publish the Manuscript Online |
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2025-10-14 07:42 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: Https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
Tumor microenvironment phenotyping guides precision therapy in unresectable pancreatic cancer
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Kai Zhao, Ming-Ming Xiao, Yong-Sheng Yang and Xiao Xiao |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Xiao Xiao, MD, PhD, Research Fellow, Department of Endocrinology, Weifang People’s Hospital, No. 151 Guangwen Street, Kuiwen District, Weifang 261041, Shandong Province, China. xiaoxiao9011@sdsmu.edu.cn |
| Key Words |
Locally advanced unresectable pancreatic cancer; Gemcitabine; Nano-albumin paclitaxel; Tumor microenvironmental resistance; Combination therapy |
| Core Tip |
This review highlights the importance of tumor microenvironment (TME) heterogeneity in treatment resistance for unresectable locally advanced pancreatic cancer. We propose a novel four-dimensional TME phenotyping framework integrating fibrosis, immunity, genomics, and metabolism to guide precision therapy. This approach enables dynamic, individualized treatment strategies and offers new prospects for improving patient outcomes. |
| Publish Date |
2025-10-14 07:42 |
| Citation |
Zhao K, Xiao MM, Yang YS, Xiao X. Tumor microenvironment phenotyping guides precision therapy in unresectable pancreatic cancer. World J Gastrointest Oncol 2025; 17(10): 109830 |
| URL |
https://www.wjgnet.com/1948-5204/full/v17/i10/109830.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v17.i10.109830 |
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