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Articles Published Processes
11/14/2025 8:23:16 AM | Browse: 27 | Download: 84
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Received |
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2025-06-03 01:26 |
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Peer-Review Started |
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2025-06-12 09:14 |
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First Decision by Editorial Office Director |
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2025-06-25 09:25 |
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Return for Revision |
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2025-06-25 09:25 |
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Revised |
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2025-07-09 04:49 |
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Publication Fee Transferred |
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2025-07-17 08:11 |
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Second Decision by Editor |
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2025-09-22 04:49 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-10-10 06:47 |
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Articles in Press |
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2025-10-10 06:47 |
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Edit the Manuscript by Language Editor |
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2025-10-18 23:00 |
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Typeset the Manuscript |
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2025-11-07 06:13 |
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Publish the Manuscript Online |
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2025-11-14 08:23 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Basic Study |
| Article Title |
Optimizing adipose-derived stem cell therapy for diabetic foot ulcers
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jing Cao, Zi-Chao Liu, Wen-Qiang An, Sen Zhang, Xin Zhang, Li-Jie Li, Hai-Lian Ji, Xiao Long and Yue-Mei Yang |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| The Zhongguancun National Independent Innovation Demonstration Zone Industrial Ecosystem Cultivation Project |
20220468089 |
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| Corresponding Author |
Yue-Mei Yang, PhD, Department of Research and Development, Beijing AegleStem Therapeutics Co., Ltd, No. 1 Yuanping North Road, Daxing District, Beijing 102600, China. maeyang@aeglestem.com |
| Key Words |
Diabetic foot ulcer; Adipose-derived stem cell; Dose-response relationship; Phosphatidylinositol 3-kinase; Notch signaling pathway |
| Core Tip |
This study systematically evaluated the dose-response relationship, administration route, persistence, and mechanisms of adipose-derived mesenchymal stem cells (ADSCs) in diabetic foot ulcer healing. Subcutaneous injection of 5 × 10⁵ ADSCs showed optimal efficacy with prolonged retention. Mechanistically, ADSCs restore the PI3K-AKT-mTOR-HIF-1α-VEGF pathway to improve angiogenesis and inhibit the overactivated Notch signaling pathway to reduce inflammation and enhance collagen deposition. These results provide critical insights into the optimization of ADSC-based therapies and offer a promising approach for treating chronic diabetic wounds. |
| Publish Date |
2025-11-14 08:23 |
| Citation |
Cao J, Liu ZC, An WQ, Zhang S, Zhang X, Li LJ, Ji HL, Long X, Yang YM. Optimizing adipose-derived stem cell therapy for diabetic foot ulcers. World J Diabetes 2025; 16(11): 109859 |
| URL |
https://www.wjgnet.com/1948-9358/full/v16/i11/109859.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v16.i11.109859 |
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