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12/22/2025 7:43:01 AM | Browse: 2 | Download: 0
Publication Name World Journal of Gastrointestinal Pathophysiology
Manuscript ID 109860
Country Singapore
Received
2025-05-26 13:40
Peer-Review Started
2025-05-26 13:40
First Decision by Editorial Office Director
2025-07-08 08:21
Return for Revision
2025-07-08 08:21
Revised
2025-07-12 02:40
Publication Fee Transferred
Second Decision by Editor
2025-10-30 02:40
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2025-10-30 10:07
Articles in Press
2025-10-30 10:07
Edit the Manuscript by Language Editor
Typeset the Manuscript
2025-12-08 07:04
Publish the Manuscript Online
2025-12-22 07:43
ISSN 2150-5330 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Systematic Reviews
Article Title Metabolic changes after hepatectomy: Implications for perioperative management and long-term outcomes
Manuscript Source Invited Manuscript
All Author List Joshua Zhuo Lee, Sandra Joanne Kar Kwan Ng and Vishal G Shelat
ORCID
Author(s) ORCID Number
Joshua Zhuo Lee http://orcid.org/0009-0008-8092-8656
Vishal G Shelat http://orcid.org/0000-0003-3988-8142
Funding Agency and Grant Number
Corresponding Author Vishal G Shelat, Adjunct Associate Professor, FRCS, Department of General Surgery, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, Singapore 308433, Singapore, Singapore. vgshelat@gmail.com
Key Words Energy consumption; Glucose metabolism; Hepatectomy; Ischemic reperfusion injury; Lipid metabolism; Liver regeneration; Liver resection; Oxygen consumption; Physiologic pringle manoeuvre; Protein metabolism
Core Tip This narrative review explores the intricate metabolic adaptations following hepatectomy, emphasising the shift towards gluconeogenesis and transient insulin resistance, increased lipid oxidation, imbalance in amino acids, and a heightened inflammatory response (especially in ischaemic reperfusion injury). It highlights the role of the liver in maintaining systemic metabolic homeostasis, and how surgical disruption affects liver metabolism. Metabolic changes post-hepatectomy influence recovery, and may serve as targets for optimising recovery, thereby guiding and enhancing perioperative care and ultimately improving surgical outcomes.
Publish Date 2025-12-22 07:43
Citation

Lee JZ, Ng SJKK, Shelat VG. Metabolic changes after hepatectomy: Implications for perioperative management and long-term outcomes. World J Gastrointest Pathophysiol 2025; 16(4): 109860

URL https://www.wjgnet.com/2150-5330/full/v16/i4/109860.htm
DOI https://dx.doi.org/10.4291/wjgp.v16.i4.109860
Full Article (PDF) WJGP-16-109860-with-cover.pdf
PRISMA 2009 Checklist 109860-PRISMA-2009-Checklist.pdf
Manuscript File 109860_Auto_Edited_011423.docx
Answering Reviewers 109860-answering-reviewers.pdf
Audio Core Tip 109860-audio.m4a
Biostatistics Review Certificate 109860-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form 109860-conflict-of-interest-statement.pdf
Copyright License Agreement 109860-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate 109860-non-native-speakers.pdf
Peer-review Report 109860-peer-reviews.pdf
Scientific Misconduct Check 109860-scientific-misconduct-check.png
Scientific Editor Work List 109860-scientific-editor-work-list.pdf
CrossCheck Report 109860-crosscheck-report.pdf