| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cardiac & Cardiovascular Systems |
| Manuscript Type |
Basic Study |
| Article Title |
Mesenchymal stem-derived exosomes enhance therapeutic benefits of exercise in isoproterenol-induced myocardial ischemia: Targeting ERK and Akt/mTOR signaling
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Asmaa M ShamsEldeen, Manar M AbdElalim, Nahed S Mohamed, Marwa M AbdelRahman, Samaa S Kamar, Dina H AbdelKader, Samar H Elsharkawy, Laila A Rashed, Salwa S Faisal, Walla’a A Osman and Asmaa M Selmy |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Asmaa M ShamsEldeen, Assistant Professor, MD, Department of Physiology, Cairo University, Al-Saray Street, El Manial, Cairo 30411, Egypt. asmaa82shamseldeen@gmail.com |
| Key Words |
Myocardial infarction; Exercise; Exosomes; Sarcoplasmic endoplasmic reticulum calcium ATPase type 2; Extracellular signal-regulated kinase 1/2; Cardiac hypertrophy; Ejection fraction |
| Core Tip |
Myocardial infarction has been extensively validated in rats for reliably inducing post-infarction metabolic and histological changes. Combined therapy may target the extracellular signal-regulated kinase and protein kinase B/mammalian target of rapamycin signaling, both of which are central to the development of hypertrophic remodeling after myocardial infarction, along with the crosstalk between matrix metalloproteinase 9 and sarcoplasmic endoplasmic reticulum calcium ATPase type 2a, which maintains the balance between hypertrophic growth and contractile function. This could offer a new therapeutic regimen for treating early maladaptive left ventricular hypertrophy. |
| Publish Date |
2025-10-25 01:11 |
| Citation |
<p>ShamsEldeen AM, AbdElalim MM, Mohamed NS, AbdelRahman MM, Kamar SS, AbdelKader DH, Elsharkawy SH, Rashed LA, Faisal SS, Osman WA, Selmy AM. Mesenchymal stem-derived exosomes enhance therapeutic benefits of exercise in isoproterenol-induced myocardial ischemia: Targeting ERK and Akt/mTOR signaling. <i>World J Stem Cells</i> 2025; 17(10): 109862</p> |
| URL |
https://www.wjgnet.com/1948-0210/full/v17/i10/109862.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v17.i10.109862 |
