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Articles Published Processes
3/6/2026 8:56:30 AM | Browse: 4 | Download: 21
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Received |
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2025-05-26 13:47 |
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Peer-Review Started |
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2025-05-26 13:47 |
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First Decision by Editorial Office Director |
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2025-06-07 03:25 |
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Return for Revision |
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2025-06-07 03:25 |
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Revised |
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2025-06-21 12:19 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-10-22 02:39 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-10-23 03:43 |
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Articles in Press |
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2025-10-23 03:43 |
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Edit the Manuscript by Language Editor |
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2025-11-02 19:56 |
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Typeset the Manuscript |
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2026-02-01 17:28 |
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Publish the Manuscript Online |
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2026-03-06 08:56 |
| ISSN |
2219-2808 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Emergency Medicine |
| Manuscript Type |
Randomized Controlled Trial |
| Article Title |
Early Inotropic Support Without Fluid Bolus Versus Standard Resuscitation in Pediatric Septic Shock: A Randomized Controlled Trial
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Swasti Keshri, Anil K Goel, Ankit Kumar Garg, Varun Anand, Sanosh Kumar Rathia and Samreen Yusuf |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Anil K Goel, Professor, Division of Pediatrics Emergency Medicine, Department of Pediatrics, All India Institute of Medical Sciences, GE Road Raipur, Raipur 492099, Chhattīsgarh, India. akgoel@aiimsraipur.edu.in |
| Key Words |
Septic shock; Fluid restriction; Inotropes; Pediatrics; No flush |
| Core Tip |
The current surviving sepsis guidelines 2020 recommend fluid boluses of 10-20 ml/kg/bolus, up to 40-60 ml/kg, but recent studies show better outcomes when fluid boluses are restricted. The FEAST trial compared a fluid bolus in children septic shock and reported a 35% higher mortality. Studies have also compared restricted fluid boluses with liberal fluid boluses, with better outcomes observed in the restricted bolus group. This study is an open-level study in children aged 1 month to 14 years, hospitalised for septic shock. Randomization was done to, Intervention Group I (early Inotropes without giving fluid bolus) or comparator, Fluid resususitation Group F, with an allocation ratio of 1:1. There was no statistically significant difference in the initial inotropic support (VIS score), the total duration of ventilation, total length of hospital stay, mortality at 48 hours, or overall mortality between the two groups. In patients with hypotensive shock, mortality at 48 hours was significantly higher in patients receiving fluid boluses. A striking 65% of the patients receiving fluid boluses developed some signs of fluid overload. |
| Publish Date |
2026-03-06 08:56 |
| Citation |
Keshri S, Goel AK, Garg AK, Anand V, Rathia SK, Yusuf S. Early Inotropic Support Without Fluid Bolus Versus Standard Resuscitation in Pediatric Septic Shock: A Randomized Controlled Trial. World J Clin Pediatr 2026; 15(1): 109864 |
| URL |
https://www.wjgnet.com/2219-2808/full/v15/i1/109864.htm |
| DOI |
https://dx.doi.org/10.5409/wjcp.v15.i1.109864 |
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