BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
11/14/2025 8:23:15 AM | Browse: 24 | Download: 91
 |
Received |
|
2025-06-17 09:37 |
|
Peer-Review Started |
|
2025-06-23 00:32 |
|
First Decision by Editorial Office Director |
|
2025-07-22 08:23 |
|
Return for Revision |
|
2025-07-22 08:23 |
|
Revised |
|
2025-07-31 04:30 |
|
Publication Fee Transferred |
|
2025-08-01 12:03 |
|
Second Decision by Editor |
|
2025-09-22 02:47 |
 |
Second Decision by Editor-in-Chief |
|
|
|
Final Decision by Editorial Office Director |
|
2025-09-29 06:14 |
|
Articles in Press |
|
2025-09-29 06:14 |
|
Edit the Manuscript by Language Editor |
|
|
|
Typeset the Manuscript |
|
2025-11-03 07:54 |
|
Publish the Manuscript Online |
|
2025-11-14 08:23 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Urology & Nephrology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Correlation of gut microbiota metabolite trimethylamine N-oxide with inflammatory levels and osteoporosis in patients with diabetic nephropathy
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Zhang-Lei Pan, Ming-Qiang Li, Jing Zhang, Ling-Yu Xue and Yan-Ping Shi |
| ORCID |
|
| Funding Agency and Grant Number |
|
| Corresponding Author |
Yan-Ping Shi, Department of Nephrology, The Second Affiliated Hospital of Shandong First Medical University, Tai’an 271000, Shandong Province, China. shiyanping1823@126.com |
| Key Words |
Diabetic nephropathy; Gut microbiota; Trimethylamine N-oxide; Inflammatory cytokines; Osteoporosis |
| Core Tip |
In recent years, with in-depth research on the gut microbiota and the emergence of concepts such as the "gut-kidney axis" and the "intestinal-bone axis", the key role of the gut microbiota and its metabolites in metabolic disorders, inflammatory responses, and target organ damage has been increasingly recognized. Trimethylamine N-oxide (TMAO) is the main metabolite produced by the gut microbiota from dietary nutrients such as phosphatidylcholine and choline, and has attracted attention due to its participation in the pathogenesis of diabetic nephropathy (DN). In this study, we aim to explore the correlation between TMAO levels and the levels of inflammatory markers and osteoporosis (OP) in patients with DN, providing a theoretical and practical basis for the early identification of high-risk patients and timely clinical intervention. The research results confirm that elevated TMAO levels may mediate the inflammatory response and bone metabolism disorder in patients with DN, thereby promoting the progression of systemic inflammation and OP. |
| Publish Date |
2025-11-14 08:23 |
| Citation |
Pan ZL, Li MQ, Zhang J, Xue LY, Shi YP. Correlation of gut microbiota metabolite trimethylamine N-oxide with inflammatory levels and osteoporosis in patients with diabetic nephropathy. World J Diabetes 2025; 16(11): 109919 |
| URL |
https://www.wjgnet.com/1948-9358/full/v16/i11/109919.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v16.i11.109919 |
© 2004-2025 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
California Corporate Number: 3537345
