Publication Name	World Journal of Orthopedics
Manuscript ID	10992
Country	Greece

Received	2014-04-29 12:13
Peer-Review Started	2014-04-30 12:22
To Make the First Decision	2014-06-27 11:56
Return for Revision	2014-06-30 12:30
Revised	2014-07-07 17:34
Second Decision	2014-10-16 15:03
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-10-16 15:35
Articles in Press	2014-10-16 15:35
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-02-26 10:40
Publish the Manuscript Online	2015-03-19 18:29

ISSN	2218-5836 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Orthopedics
Manuscript Type	Minireviews
Article Title	Use of demineralized bone matrix in the extremities
Manuscript Source	Invited Manuscript
All Author List	Georgios I Drosos, Panagiotis Touzopoulos, Athanasios Ververidis, Konstantinos Tilkeridis and Konstantinos Kazakos
Funding Agency and Grant Number
Corresponding Author	Georgios I Drosos, MD, PhD, Assistant Professor of Orthopaedics, Department of Orthopaedic Surgery, Medical School, Democritus University of Thrace, University General Hospital of Alexandroupolis, 68100 Alexandroupolis, Greece. drosos@otenet.gr
Key Words	Bone; Grafting; Allograft; Demineralized bone matrix; Non-union
Core Tip	Demineralized bone matrix (DBM) is an allograft product that was found to be safe as an option of bone grafting. As far as its effectiveness is concerned, and according to the existing literature: (1) there is a good evidence for its use in bone cysts combined with autologous marrow aspirate; (2) in fracture nonunion and filling the defects after tumor surgery DBM used alone or combined with other grafting material are supported by a lower quality studies; and (3) there is insufficient evidence to make a treatment recommendation for DBM use in fracture treatment of other applications. Furthermore, according to the existing literature there are results of clinical use of only a few DBM products and thus the recommendation concerning the DBM use should probably also be referred to these specific products and not to any DBM product.
Publish Date	2015-03-19 18:29
Citation	Drosos GI, Touzopoulos P, Ververidis A, Tilkeridis K, Kazakos K. Use of demineralized bone matrix in the extremities. World J Orthop 2015; 6(2): 269-277
URL	http://www.wjgnet.com/2218-5836/full/v6/i2/269.htm
DOI	http://dx.doi.org/10.5312/wjo.v6.i2.269

Full Article (PDF)	WJO-6-269.pdf
Full Article (Word)	WJO-6-269.doc
Manuscript File	10992-Review.doc
Answering Reviewers	10992-Answering reviewers.pdf
Copyright License Agreement	10992-Copyright assignment.pdf
Peer-review Report	10992-Peer review(s).pdf
Scientific Misconduct Check	10992-CrossCheck.jpg
Scientific Editor Work List	10992-Scientific editor work list.pdf