| ISSN |
2220-3230 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cardiac & Cardiovascular Systems |
| Manuscript Type |
Minireviews |
| Article Title |
Chronic heart failure and heart transplantation: The relationship between autonomic function and cardiac performance
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Lin-Zhi Wu, Yi-Ning Huang, Yue Chen, Yu-Qiu Ji, Yi-Wen Jin, Cai-Xian Chen, Si-Yu Zhuang, Bin Xu, You-Bing Xia and Tian-Cheng Xu |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Key Research and Development Program, "Modernization of Traditional Chinese Medicine" Key Special Project |
2022YFC3500704 |
| Project for Supporting Young Talents of China Association of Acupuncture and Moxibustion |
2024-2026ZGZJXH-QNRC005 |
|
| Corresponding Author |
Tian-Cheng Xu, CEO, Chairman, Consultant, Founder, Head, MD, PhD, Key Laboratory of Acupuncture and Medicine Research of Ministry of Education, Nanjing University of Chinese Medicine, No. 138 Xianlin Avenue, Qixia District, Nanjing 210023, Jiangsu Province, China. xtc@njucm.edu.cn |
| Key Words |
Chronic heart failure; Autonomic nervous system; Heart transplantation; Sympathetic nervous system; Parasympathetic nervous system |
| Core Tip |
Autonomic nervous system (ANS) imbalance—marked by sympathetic overactivity and parasympathetic withdrawal—drives chronic heart failure (CHF) progression through oxidative stress, fibrosis, and catecholamine toxicity. Neuromodulation therapies aim to restore ANS balance and improve outcomes. After heart transplantation, autonomic dysfunction from denervation increases the risk of arrhythmias and hemodynamic instability, underscoring the prognostic value of partial reinnervation. This minireview highlights ANS modulation as a vital therapeutic target linking CHF management and post-transplant care to optimize cardiac function and long-term survival. |
| Publish Date |
2025-11-19 05:58 |
| Citation |
Wu LZ, Huang YN, Chen Y, Ji YQ, Jin YW, Chen CX, Zhuang SY, Xu B, Xia YB, Xu TC. Chronic heart failure and heart transplantation: The relationship between autonomic function and cardiac performance. World J Transplant 2025; 15(4): 109951 |
| URL |
https://www.wjgnet.com/2220-3230/full/v15/i4/109951.htm |
| DOI |
https://dx.doi.org/10.5500/wjt.v15.i4.109951 |
