| ISSN |
1948-9366 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Clinical Trials Study |
| Article Title |
Treatment of human umbilical cord-derived mesenchymal stem cells for hepatitis B virus-associated decompensated liver cirrhosis: A clinical trial
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xian Qin, Jing Chen, Hua-Ni Zhang, Li Du, Yan Ma, Yi Li, Yu Lu, Ya-Ting Wang, Liu-Fang Wu, Zi-Hui Yu, Meng-Jing Hu, Li-Jun Li, Bo Liao, Zhen Li, Zhi-Yong Yang, Kun Li and Yu-Feng Yuan |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Foundation of Health Commission of Hubei Province |
No. WJ2019H053 |
| Natural Science Foundation of Hubei Province |
No. 2023AFB169 |
| Foundation of Health Commission of Hubei Province |
No. ZY2021Q019 |
| Open Fund Hubei Provincial Clinical Research Center for Umbilical Cord Blood Hematopoietic Stem Cells, Taihe Hospital |
No. 2024SCOF008 |
|
| Corresponding Author |
Yu-Feng Yuan, MD, Professor, Department of Hepatobiliary and Pancreatic Surgery, Zhongnan Hospital of Wuhan University, No. 169 Donghu Road Wuchang District, Wuhan 430000, Hubei Province, China. yuanyf1971@whu.edu.cn |
| Key Words |
Umbilical cord-derived mesenchymal stem cells; Decompensated liver cirrhosis; Hepatitis virus B; Liver function; Clinical trial |
| Core Tip |
This pioneering trial demonstrates that peripheral vein infusion of human umbilical cord-derived mesenchymal stem cells provides rapid and durable liver function improvement in HBV-related decompensated cirrhosis. Key results include: (1) Improvement in liver function sustained for almost 3 months; (2) Coagulation improvement and interleukin-8 reduction sustained > 3 months; (3) 100% 6-month survival across all doses and exceptional 2-year survival (66.7%-100%); (4) Weak dose-efficacy correlation suggesting even low-dose efficacy; and (5) Promising safety profile. human umbilical cord-derived mesenchymal stem cells represent a novel therapy for end-stage liver disease, warranting large-scale validation. |
| Publish Date |
2025-09-24 09:01 |
| Citation |
Qin X, Chen J, Zhang HN, Du L, Ma Y, Li Y, Lu Y, Wang YT, Wu LF, Yu ZH, Hu MJ, Li LJ, Liao B, Li Z, Yang ZY, Li K, Yuan YF. Treatment of human umbilical cord-derived mesenchymal stem cells for hepatitis B virus-associated decompensated liver cirrhosis: A clinical trial. World J Gastrointest Surg 2025; 17(9): 109980 |
| URL |
https://www.wjgnet.com/1948-9366/full/v17/i9/109980.htm |
| DOI |
https://dx.doi.org/10.4240/wjgs.v17.i9.109980 |
