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10/16/2025 9:32:19 AM | Browse: 13 | Download: 23
Publication Name World Journal of Orthopedics
Manuscript ID 110009
Country Spain
Received
2025-05-28 09:23
Peer-Review Started
2025-05-28 09:23
To Make the First Decision
Return for Revision
2025-06-07 02:59
Revised
2025-06-10 17:32
Second Decision
2025-09-08 02:46
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief
2025-09-08 07:33
Articles in Press
2025-09-08 07:33
Publication Fee Transferred
Edit the Manuscript by Language Editor
2025-09-13 18:30
Typeset the Manuscript
2025-09-28 02:25
Publish the Manuscript Online
2025-10-16 09:32
ISSN 2218-5836 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Orthopedics
Manuscript Type Minireviews
Article Title Nanotechnology for pain management in orthopedic surgery
Manuscript Source Invited Manuscript
All Author List Emerito Carlos Rodriguez-Merchan, Javier De Andres-Ares, Alberto D Delgado-Martinez and William J Ribbans
ORCID
Author(s) ORCID Number
Emerito Carlos Rodriguez-Merchan http://orcid.org/0000-0002-6360-0113
Javier De Andres-Ares http://orcid.org/0000-0002-4385-9056
Alberto D Delgado-Martinez http://orcid.org/0000-0003-3308-4047
William J Ribbans http://orcid.org/0000-0002-3612-2857
Funding Agency and Grant Number
Corresponding Author Emerito Carlos Rodriguez-Merchan, MD, PhD, Department of Orthopedic Surgery, Hospital Universitario La Paz-IdiPaz, Paseo de la Castellana 261, Madrid 28046, Spain. ecrmerchan@hotmail.com
Key Words Orthopedic surgery; Pain management; Nanotechnology; Nanotechnology-based transporter; Nanocapacitor-based device/patch
Core Tip Nanotechnology offers encouraging alternatives for the management of pain in orthopedic surgery either as drug transporters or as capacitor device/patch. As drug transporter-based formulations for morphine, bupivacaine and lidocaine, nanotechnology permits for lengthening the duration of these drugs, and increasing the effective analgesic dose, consequently diminishing potential drug toxicity. The nanocapacitor-based technology, the NeuroCupleTM device, possibly represents an efficacious non-pharmacology method.
Publish Date 2025-10-16 09:32
Citation <p>Rodriguez-Merchan EC, De Andres-Ares J, Delgado-Martinez AD, Ribbans WJ. Nanotechnology for pain management in orthopedic surgery. <i>World J Orthop</i> 2025; 16(10): 110009</p>
URL https://www.wjgnet.com/2218-5836/full/v16/i10/110009.htm
DOI https://dx.doi.org/10.5312/wjo.v16.i10.110009
Full Article (PDF) WJO-16-110009-with-cover.pdf
Manuscript File 110009_Auto_Edited_083243.docx
Answering Reviewers 110009-answering-reviewers.pdf
Audio Core Tip 110009-audio.m4a
Conflict-of-Interest Disclosure Form 110009-conflict-of-interest-statement.pdf
Copyright License Agreement 110009-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate 110009-non-native-speakers.pdf
Peer-review Report 110009-peer-reviews.pdf
Scientific Misconduct Check 110009-scientific-misconduct-check.png
Scientific Editor Work List 110009-scientific-editor-work-list.pdf
CrossCheck Report 110009-crosscheck-report.pdf