Publication Name	World Journal of Clinical Oncology
Manuscript ID	110031
Country	China

Received	2025-05-28 07:39
Peer-Review Started	2025-05-28 07:39
To Make the First Decision
Return for Revision	2025-06-07 05:57
Revised	2025-06-18 05:53
Second Decision	2025-07-30 02:40
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-07-31 08:55
Articles in Press	2025-07-31 08:55
Publication Fee Transferred	2025-06-19 01:30
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-08-28 08:38
Publish the Manuscript Online	2025-09-23 06:48

ISSN	2218-4333 (online)
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Category	Womens Studies
Manuscript Type	Observational Study
Article Title	Fertility anxiety partially mediates depression and recurrence fear in reproductive-age cervical cancer patients: A cross-sectional study
Manuscript Source	Unsolicited Manuscript
All Author List	Xin-Ying He, Ying Huang, Cheng-Ping Qiao, Jiao Ma, Xue Han, Xue-Mei Fan and Qin Chen
ORCID	Author(s) ORCID Number Xin-Ying He http://orcid.org/0009-0005-0762-8145 Qin Chen http://orcid.org/0009-0001-7183-5668
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation Youth Project 72204123 China Social Welfare Foundation- Nurse Care Fund HLCXKT-20230130
Corresponding Author	Qin Chen, Chief Nurse, Department of Gynecological Oncology, Women's Hospital of Nanjing Medical University , Nanjing Women and Children's Healthcare Hospital, No. 123 Tianfei Lane, Mochou Road, Qinhuai District, Nanjing 210004, Jiangsu Province, China. qin@njmu.edu.cn
Key Words	Uterine cervical neoplasms; Depression; Fear; Fertility preservation; Mediation analysis; Reproductive age
Core Tip	This study establishes reproductive concerns as a significant partial mediator (accounting for 28.1% of the total effect, β-indirect = 0.152, P < 0.001) between depression and fear of recurrence in 208 childbearing-age cervical cancer patients, using validated scales (Patient Health Questionnaire-9, Reproductive Concerns After Cancer Scale, Fear of Cancer Recurrence Questionnaire) in a cross-sectional design. Strong correlations were observed (reproductive concerns with depression: r = 0.477; with fear of recurrence: r = 0.426), highlighting that depression amplifies fear of recurrence both directly (β-direct = 0.389) and indirectly via fertility-related distress. Given cervical cancer's direct impact on reproductive function and cultural childbearing expectations in populations like China, targeted oncofertility counseling and psychosocial interventions addressing reproductive concerns may concurrently alleviate depressive symptoms and recurrence fears, offering a dual-benefit strategy for survivorship care.
Publish Date	2025-09-23 06:48
Citation	<p>He XY, Huang Y, Qiao CP, Ma J, Han X, Fan XM, Chen Q. Fertility anxiety partially mediates depression and recurrence fear in reproductive-age cervical cancer patients: A cross-sectional study. <i>World J Clin Oncol</i> 2025; 16(9): 110031</p>
URL	https://www.wjgnet.com/2218-4333/full/v16/i9/110031.htm
DOI	https://dx.doi.org/10.5306/wjco.v16.i9.110031

Full Article (PDF)	WJCO-16-110031-with-cover.pdf
STROBE Statement	110031-STROBE-statement.pdf
Manuscript File	110031_Auto_Edited_031057.docx
Answering Reviewers	110031-answering-reviewers.pdf
Audio Core Tip	110031-audio.mp3
Biostatistics Review Certificate	110031-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	110031-conflict-of-interest-statement.pdf
Copyright License Agreement	110031-copyright-assignment.pdf
Signed Informed Consent Form(s) or Document(s)	110031-informed-consent-statement.pdf
Institutional Review Board Approval Form or Document	110031-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate	110031-non-native-speakers.pdf
Peer-review Report	110031-peer-reviews.pdf
Scientific Misconduct Check	110031-scientific-misconduct-check.png
Scientific Editor Work List	110031-scientific-editor-work-list.pdf
CrossCheck Report	110031-crosscheck-report.pdf