| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Biochemistry & Molecular Biology |
| Manuscript Type |
Minireviews |
| Article Title |
Mitochondrial transplantation and platelet rich plasma for the treatment of non-alcoholic fatty liver disease
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Manuel Alejandro Vargas-Vargas, Marcela González-Montoya, Olin Torres-Isidro, Omar Ortiz-Avila, Elizabeth Calderón-Cortés and Christian Cortés-Rojo |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Programa Proyectos de Investigación financiados 2025, Coordinación de Investigación Científica, Universidad Michoacana de San Nicolás de Hidalgo, México |
|
| Secretaría de Ciencia, Humanidades, Tecnología e Innovación, (SECIHTI), México Awarded Postdoctoral Fellowships |
472544 |
| Secretaría de Ciencia, Humanidades, Tecnología e Innovación, (SECIHTI), México Awarded Postdoctoral Fellowships |
589763 |
|
| Corresponding Author |
Christian Cortés-Rojo, PhD, Professor, Instituto de Investigaciones Químico - Biológicas, Universidad Michoacana de San Nicolás de Hidalgo, Edificio B-3, Ciudad Universitaria, Avenida Fco J Mujica, Morelia 58030, Michoacán, Mexico. christian.cortes@umich.mx |
| Key Words |
Non-alcoholic fatty liver disease; Steatohepatitis; Inflammation; Cirrhosis; Oxidative stress; Electron transport chain; Tissue regeneration; Hepatocyte; Steatosis; Mitochondria |
| Core Tip |
Liver diseases driven by mitochondrial dysfunction and oxidative stress have not yet been effectively treated, creating a need for novel therapeutic solutions. Mitochondrial transplantation restores energy metabolism, while platelet rich plasma (PRP) therapy reduces fibrosis via growth factors. This is the first review to propose the combination of mitochondrial transplantation and PRP as a novel therapeutic strategy for non-alcoholic fatty liver disease. The strategy addresses mitochondrial dysfunction, oxidative stress, and fibrosis while promoting liver regeneration, offering a promising alternative where pharmacological treatments are limited. |
| Publish Date |
2025-10-27 10:57 |
| Citation |
Vargas-Vargas MA, González-Montoya M, Torres-Isidro O, Ortiz-Avila O, Calderón-Cortés E, Cortés-Rojo C. Mitochondrial transplantation and platelet rich plasma for the treatment of non-alcoholic fatty liver disease. World J Hepatol 2025; 17(10): 110054 |
| URL |
https://www.wjgnet.com/1948-5182/full/v17/i10/110054.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v17.i10.110054 |
