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Articles Published Processes
11/27/2025 7:53:54 AM | Browse: 9 | Download: 56
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Received |
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2025-05-29 06:19 |
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Peer-Review Started |
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2025-06-06 09:02 |
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First Decision by Editorial Office Director |
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2025-06-17 09:20 |
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Return for Revision |
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2025-06-17 09:20 |
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Revised |
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2025-07-01 08:17 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-10-09 02:35 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-10-10 08:00 |
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Articles in Press |
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2025-10-10 08:00 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-11-18 00:52 |
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Publish the Manuscript Online |
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2025-11-27 07:53 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Minireviews |
| Article Title |
Non-invasive blood biomarkers for assessment of liver fibrosis in metabolic dysfunction-associated steatotic liver disease
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Yan-Hua Zhao, Shu-Sheng Leng, Yan Wang, Fa-Zhi Kui and Wei Gan |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
No. 82402719 |
| Sichuan Science and Technology Program |
No. 2025ZNSFSC1553 |
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| Corresponding Author |
Wei Gan, PhD, Professor, Department of Laboratory Medicine, West China Hospital, Sichuan University, Sichuan Clinical Research Center for Laboratory Medicine, and Clinical Laboratory Medicine Research Center of West China Hospital, No. 37 Guoxue Lane, Wuhou District, Chengdu 610041, Sichuan Province, China. 2004ganwei@scu.edu.cn |
| Key Words |
Metabolic dysfunction-associated steatotic liver disease; Non-invasive test; Blood biomarkers; Liver fibrosis; Patented panel |
| Core Tip |
Current biomarkers (fibrosis-4, non-alcoholic fatty liver disease fibrosis score) provide accessible first-line screening for metabolic dysfunction-associated steatotic liver disease (MASLD) fibrosis but require age/obesity-adjusted thresholds. Patented panels (enhanced liver fibrosis, FibroMeter) enhance precision through metabolic/extracellular matrix markers yet need MASLD-specific validation. Emerging biomarkers (propeptide of type 3 collagen, Mac-2 binding protein glycosylation isomer, epigenetic regulators like proliferator-activated receptor-γ methylation, angiopoietin-like proteins such as angiopoietin-like protein a family of eight glycoproteins) show monitoring potential but need validation. No single biomarker replaces biopsy. Combining existing tools with novel multi-omics approaches and MASLD-specific diagnostic frameworks is critical for improving clinical outcomes in this epidemic. |
| Publish Date |
2025-11-27 07:53 |
| Citation |
Zhao YH, Leng SS, Wang Y, Kui FZ, Gan W. Non-invasive blood biomarkers for assessment of liver fibrosis in metabolic dysfunction-associated steatotic liver disease. World J Hepatol 2025; 17(11): 110080 |
| URL |
https://www.wjgnet.com/1948-5182/full/v17/i11/110080.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v17.i11.110080 |
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