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Articles Published Processes
10/27/2025 10:57:52 AM | Browse: 0 | Download: 0
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Received |
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2025-05-29 06:15 |
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Peer-Review Started |
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2025-06-06 09:02 |
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To Make the First Decision |
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Return for Revision |
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2025-06-24 10:58 |
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Revised |
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2025-07-03 15:19 |
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Second Decision |
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2025-09-18 02:54 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-09-18 08:57 |
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Articles in Press |
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2025-09-18 08:57 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-10-17 06:14 |
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Publish the Manuscript Online |
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2025-10-27 10:57 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
Hepatitis B functional cure: Current and future perspective
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Sudheer Marrapu, Jinit R Soni, Kislaya Kamal and Ramesh Kumar |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Ramesh Kumar, MD, Department of Gastroenterology, All India Institute of Medical Sciences, Phulwari Sharif, Patna 801507, India. docrameshkr@gmail.com |
| Key Words |
Hepatitis B; Hepatitis B surface antigen seroclearance; Functional cure; Surface antigen; Virological cure |
| Core Tip |
Achieving a functional cure for chronic hepatitis B, defined as sustained hepatitis B surface antigen loss with undetectable hepatitis B virus (HBV) DNA, remains challenging due to the persistence of covalently closed circular DNA (cccDNA) and immune dysfunction. While standard therapies, such as nucleos(t)ide analogues and pegylated interferon, yield low seroclearance rates, novel therapeutics targeting various steps in the life cycle of HBV-such as cccDNA silencing, RNA degradation, capsid modulation, and immune restoration- show promise. Combinatorial approaches, including small interfering RNA, checkpoint inhibitors, and therapeutic vaccines, are being evaluated. Identifying predictive biomarkers and optimizing the timing for treatment cessation may improve treatment outcomes. |
| Publish Date |
2025-10-27 10:57 |
| Citation |
<p>Marrapu S, Soni JR, Kamal K, Kumar R. Hepatitis B functional cure: Current and future perspective. <i>World J Hepatol</i> 2025; 17(10): 110107</p> |
| URL |
https://www.wjgnet.com/1948-5182/full/v17/i10/110107.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v17.i10.110107 |
© 2004-2025 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
California Corporate Number: 3537345
