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Articles Published Processes
1/14/2026 8:09:16 AM | Browse: 3 | Download: 14
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Received |
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2025-05-29 06:10 |
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Peer-Review Started |
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2025-06-06 09:03 |
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First Decision by Editorial Office Director |
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2025-07-04 07:10 |
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Return for Revision |
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2025-07-04 07:10 |
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Revised |
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2025-07-31 08:25 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-10-21 00:27 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-12-02 09:42 |
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Articles in Press |
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2025-12-02 09:42 |
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Edit the Manuscript by Language Editor |
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2025-12-07 07:20 |
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Typeset the Manuscript |
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2026-01-04 06:10 |
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Publish the Manuscript Online |
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2026-01-14 08:09 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Neurosciences |
| Manuscript Type |
Minireviews |
| Article Title |
Targeting N-methyl-D-aspartate 2B receptor in painful diabetic neuropathy - mechanisms, challenges, and emerging therapeutics
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Nayab Khalid, Nazlahshaniza Shafin, Idris Long, Hidani Hasim and Che Aishah Nazariah Ismail |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Che Aishah Nazariah Ismail, Lecturer, PhD, Department of Physiology, School of Medical Sciences, Universiti Sains Malaysia Health Campus, Kubang Kerian 16150, Kelantan, Malaysia. aishahnazariah@usm.my |
| Key Words |
Painful diabetic neuropathy; N-methyl-D-aspartate receptor-2B; Chronic pain; Oxidative stress; Inflammation; Nociception; Glia |
| Core Tip |
In the pathophysiology of painful diabetic neuropathy, N-methyl-D-aspartate receptor-2B plays a pivotal role. This minireview highlights how it contributes to oxidative stress, neuroinflammation, and central sensitization. It discusses the experimental and clinical data linking N-methyl-D-aspartate receptor-2B upregulation with chronic pain, evaluates emerging therapeutics targeting this receptor, and outlines translational challenges. Understanding the receptor’s molecular interplay with glial cells and signaling pathways provides valuable insight for developing multi-targeted or precision-based therapies to improve painful diabetic neuropathy management. |
| Publish Date |
2026-01-14 08:09 |
| Citation |
Khalid N, Shafin N, Long I, Hasim H, Ismail CAN. Targeting N-methyl-D-aspartate 2B receptor in painful diabetic neuropathy - mechanisms, challenges, and emerging therapeutics. World J Diabetes 2026; 17(1): 110108 |
| URL |
https://www.wjgnet.com/1948-9358/full/v17/i1/110108.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v17.i1.110108 |
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