Publication Name	World Journal of Gastroenterology
Manuscript ID	110112
Country	Türkiye

Received	2025-05-30 06:25
Peer-Review Started	2025-05-30 06:25
To Make the First Decision
Return for Revision	2025-06-04 03:43
Revised	2025-06-14 10:40
Second Decision	2025-07-18 02:43
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-07-18 05:11
Articles in Press	2025-07-18 05:11
Publication Fee Transferred	2025-06-16 10:16
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-08-04 01:49
Publish the Manuscript Online	2025-08-07 06:39

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Cohort Study
Article Title	Outcomes of 5-aminosalicylates withdrawal due to non-adherence in ulcerative colitis patients: A step toward evaluating intermittent therapy
Manuscript Source	Unsolicited Manuscript
All Author List	Ali Atay, Mucahit Ergul, Oguz Ozturk, Kadir C Acun, Yavuz Cagir, Muhammed B Durak and Ilhami Yuksel
ORCID	Author(s) ORCID Number Ali Atay http://orcid.org/0000-0001-6488-8289 Mucahit Ergul http://orcid.org/0000-0002-0856-229X Oguz Ozturk http://orcid.org/0000-0003-1558-8882 Kadir C Acun http://orcid.org/0000-0003-0591-746X Yavuz Cagir http://orcid.org/0000-0002-5676-9914 Muhammed B Durak http://orcid.org/0000-0001-9047-6122 Ilhami Yuksel http://orcid.org/0000-0002-9730-2309
Funding Agency and Grant Number
Corresponding Author	Ilhami Yuksel, Professor, Department of Gastroenterology, Faculty of Medicine, Ankara Yildirim Beyazit University, İhsan Dogramaci Cad. Bilkent, Ankara 06800, Türkiye. yukselilhami@hotmail.com
Key Words	Inflammatory bowel disease; Ulcerative colitis; 5-aminosalicylates; Treatment withdrawal; Relapse; Intermittent therapy
Core Tip	In this study, 5-aminosalicylate (5-ASA) withdrawal was observed in 3.4% of patients with ulcerative colitis (UC). Almost half of them developed a relapse. The majority of patients who experienced relapse were treated with 5-ASA monotherapy, while one-fourth of them required corticosteroids. No patients required biological agents, hospitalization, or surgery. Based on our long-term real-world data, intermittent therapy may represent a potentially safe and feasible strategy in terms of relapse risk in patients with UC. Notably, in patients who have sustained long-term clinical remission, a treatment interruption of up to one year may be considered safe.
Publish Date	2025-08-07 06:39
Citation	<p>Atay A, Ergul M, Ozturk O, Acun KC, Cagir Y, Durak MB, Yuksel I. Outcomes of 5-aminosalicylates withdrawal due to non-adherence in ulcerative colitis patients: A step toward evaluating intermittent therapy. <i>World J Gastroenterol</i> 2025; 31(30): 110112</p>
URL	https://www.wjgnet.com/1007-9327/full/v31/i30/110112.htm
DOI	https://dx.doi.org/10.3748/wjg.v31.i30.110112

Full Article (PDF)	WJG-31-110112-with-cover.pdf
STROBE Statement	110112-STROBE-statement.pdf
Manuscript File	110112_Auto_Edited_073242.docx
Answering Reviewers	110112-answering-reviewers.pdf
Audio Core Tip	110112-audio.m4a
Biostatistics Review Certificate	110112-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	110112-conflict-of-interest-statement.pdf
Copyright License Agreement	110112-copyright-assignment.pdf
Signed Informed Consent Form(s) or Document(s)	110112-informed-consent-statement.pdf
Institutional Review Board Approval Form or Document	110112-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate	110112-non-native-speakers.pdf
Supplementary Material	110112-supplementary-material.pdf
Peer-review Report	110112-peer-reviews.pdf
Scientific Misconduct Check	110112-scientific-misconduct-check.png
Scientific Editor Work List	110112-scientific-editor-work-list.pdf
CrossCheck Report	110112-crosscheck-report.pdf