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Articles Published Processes
8/5/2025 8:25:47 AM | Browse: 29 | Download: 72
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Received |
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2025-05-30 05:23 |
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Peer-Review Started |
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2025-05-30 05:23 |
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To Make the First Decision |
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Return for Revision |
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2025-06-06 07:05 |
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Revised |
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2025-06-21 01:04 |
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Second Decision |
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2025-07-09 02:37 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-07-09 05:54 |
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Articles in Press |
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2025-07-09 05:54 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-07-22 12:45 |
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Publish the Manuscript Online |
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2025-08-05 08:25 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Editorial |
| Article Title |
Targeting tumor vascular endothelial cells for hepatocellular carcinoma treatment
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Chun-Ye Zhang and Ming Yang |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Ming Yang, Assistant Professor, PhD, Department of Surgery, University of Connecticut, School of Medicine, 263 Farmington Avenue, Farmington, CT 06030, United States. minyang@uchc.edu |
| Key Words |
Hepatocellular carcinoma; Vascular endothelial cells; Angiogenesis; Molecular signaling pathways; Therapy |
| Core Tip |
Hepatocellular carcinoma (HCC) is a leading cause of cancer death worldwide, without effective treatment strategies for unresectable HCC. Tumor vascular endothelial cells have distinct features and functions from liver sinusoidal endothelial cells, lining the interior layer of cancer vascular vessels, and they contribute to tumor angiogenesis, proliferation, migration, and therapeutic resistance. Targeting liver tumor vascular endothelial cell molecular signaling pathways in the promotion of liver fibrosis, immunosuppressive cell infiltration, angiogenesis, and secretion of pro-metastatic factors is a promising strategy for HCC therapy or as a synergistic treatment. |
| Publish Date |
2025-08-05 08:25 |
| Citation |
<p>Zhang CY, Yang M. Targeting tumor vascular endothelial cells for hepatocellular carcinoma treatment. <i>World J Gastroenterol</i> 2025; 31(29): 110114</p> |
| URL |
https://www.wjgnet.com/1007-9327/full/v31/i29/110114.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v31.i29.110114 |
© 2004-2025 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
California Corporate Number: 3537345
