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10/15/2025 9:03:27 AM | Browse: 34 | Download: 172
Publication Name World Journal of Diabetes
Manuscript ID 110138
Country Taiwan
Received
2025-05-30 06:08
Peer-Review Started
2025-05-30 08:15
First Decision by Editorial Office Director
2025-06-13 02:19
Return for Revision
2025-06-13 02:19
Revised
2025-06-26 04:19
Publication Fee Transferred
2025-06-27 02:04
Second Decision by Editor
2025-09-03 09:08
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2025-09-18 07:14
Articles in Press
2025-09-18 07:14
Edit the Manuscript by Language Editor
Typeset the Manuscript
2025-10-09 01:08
Publish the Manuscript Online
2025-10-15 09:03
ISSN 1948-9358 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Genetics & Heredity
Manuscript Type Retrospective Cohort Study
Article Title Polygenic risk score for predicting diabetic retinopathy in patients with type 2 diabetes: A twenty-year follow-up study
Manuscript Source Unsolicited Manuscript
All Author List Yu-Chuen Huang, Wen-Ling Liao, Hui-Ju Lin, Yu-Te Huang, Ya-Wen Chang, Jai-Sing Yang, Angel L Weng and Fuu-Jen Tsai
ORCID
Author(s) ORCID Number
Yu-Chuen Huang http://orcid.org/0000-0001-7757-2283
Fuu-Jen Tsai http://orcid.org/0000-0002-1373-245X
Funding Agency and Grant Number
Corresponding Author Fuu-Jen Tsai, Department of Medical Research, China Medical University Hospital, No. 2 Yuh-Der Road, Taichung 404, Taiwan. 000704@tool.caaumed.org.tw
Key Words Single nucleotide polymorphisms; Genome-wide association study; Polygenic risk score; Type 2 diabetes; Diabetic retinopathy
Core Tip This population-based study developed a polygenic risk score (PRS) to assess diabetic retinopathy (DR) risk in patients with type 2 diabetes. Findings show that individuals with higher PRS are more likely to develop DR, including severe forms, over a 20-year period. Our study highlights the genetic basis of DR and introduces a potential tool for risk stratification and personalized screening in patients with type 2 diabetes. The PRS may help identify high-risk patients who could benefit from more frequent ophthalmological assessments and earlier intervention.
Publish Date 2025-10-15 09:03
Citation

Huang YC, Liao WL, Lin HJ, Huang YT, Chang YW, Yang JS, Weng AL, Tsai FJ. Polygenic risk score for predicting diabetic retinopathy in patients with type 2 diabetes: A twenty-year follow-up study. World J Diabetes 2025; 16(10): 110138

URL https://www.wjgnet.com/1948-9358/full/v16/i10/110138.htm
DOI https://dx.doi.org/10.4239/wjd.v16.i10.110138
Full Article (PDF) WJD-16-110138-with-cover.pdf
STROBE Statement 110138-STROBE-statement.pdf
Manuscript File 110138_Auto_Edited_095137.docx
Answering Reviewers 110138-answering-reviewers.pdf
Audio Core Tip 110138-audio.mp3
Biostatistics Review Certificate 110138-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form 110138-conflict-of-interest-statement.pdf
Copyright License Agreement 110138-copyright-assignment.pdf
Signed Informed Consent Form(s) or Document(s) 110138-informed-consent-statement.pdf
Institutional Review Board Approval Form or Document 110138-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate 110138-non-native-speakers.pdf
Peer-review Report 110138-peer-reviews.pdf
Journal Editor-in-Chief Review Report 110138-journal-editor-in-chief.pdf
Scientific Misconduct Check 110138-scientific-misconduct-check.png
Scientific Editor Work List 110138-scientific-editor-work-list.pdf
CrossCheck Report 110138-crosscheck-report.pdf