| ISSN |
2218-5836 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Pediatrics |
| Manuscript Type |
Review |
| Article Title |
Internal diseases and molecular mechanisms causing slipped capital femoral epiphysis in children
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Yi-Fan Chen, Ke Ning, Yu-Yin Xie, Can Liu, Yi-Tong Ding, Zhong-Wen Tang, Jie Wen, Sheng Xiao and Yu-Fei Li |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Science project of Hunan Provincial Healthy Commission |
No. 20230844 |
|
| Corresponding Author |
Jie Wen, Department of Pediatric Orthopedics, Hunan Provincial People’s Hospital, The First Affiliated Hospital of Hunan Normal University, No. 61 West Jiefang Road, Changsha 410013, Hunan Province, China. cashwj@qq.com |
| Key Words |
Slipped capital femoral epiphysis; Hypothyroidism; Growth hormone abnormalities; Hypogonadism; Obesity-related hormonal imbalances |
| Core Tip |
Slipped capital femoral epiphysis is an adolescent hip disorder causing hip pain, abnormal gait, and potential avascular necrosis. Although its exact cause is unknown, risk factors include endocrine disorders (e.g., hypothyroidism, growth hormone abnormalities), metabolic conditions (e.g., obesity, renal osteodystrophy), and genetic diseases (e.g., COL2A1 mutations). This article summarizes these associated conditions and explores potential mechanisms involving growth plate chondrocyte dysfunction, hormonal imbalances, and inflammatory/metabolic factors, aiming to support slipped capital femoral epiphysisprevention and treatment. |
| Publish Date |
2025-11-14 07:35 |
| Citation |
Chen YF, Ning K, Xie YY, Liu C, Ding YT, Tang ZW, Wen J, Xiao S, Li YF. Internal diseases and molecular mechanisms causing slipped capital femoral epiphysis in children. World J Orthop 2025; 16(11): 110155 |
| URL |
https://www.wjgnet.com/2218-5836/full/v16/i11/110155.htm |
| DOI |
https://dx.doi.org/10.5312/wjo.v16.i11.110155 |
