Publication Name	World Journal of Hepatology
Manuscript ID	110162
Country	Mexico

Received	2025-05-30 01:38
Peer-Review Started	2025-05-30 03:08
To Make the First Decision
Return for Revision	2025-06-23 01:39
Revised	2025-06-27 23:32
Second Decision	2025-08-01 02:40
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-08-01 11:56
Articles in Press	2025-08-01 11:56
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-09-17 03:17
Publish the Manuscript Online	2025-09-25 11:24

ISSN	1948-5182 (online)
Open Access	The first time an abbreviation appears in the manuscript, please label it with its full name.
Copyright	© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Letter to the Editor
Article Title	Silymarin-alpha lipoic acid and metabolic dysfunction-associated steatotic liver disease: Insights and methodological considerations
Manuscript Source	Unsolicited Manuscript
All Author List	Froylan David Martínez-Sánchez, Sophia Eugenia Martínez-Vázquez, Ricardo Gutiérrez-Monterrubio, Sergio Muñoz-Martínez and Ignacio Garcia-Juarez
ORCID	Author(s) ORCID Number Froylan David Martínez-Sánchez http://orcid.org/0000-0002-2719-1105 Sophia Eugenia Martínez-Vázquez http://orcid.org/0000-0001-5156-9932 Ignacio Garcia-Juarez http://orcid.org/0000-0003-2400-1887
Funding Agency and Grant Number
Corresponding Author	Ignacio Garcia-Juarez, MD, Professor, Department of Gastroenterology and Liver Transplant Unit, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Av. Vasco de Quiroga 15, Belisario Domínguez Secc 16., Mexico City 14080, Mexico. drinter77@gmail.com
Key Words	Metabolic dysfunction-associated steatotic liver disease; Silymarin; Alpha lipoic acid; dietary supplements; Clinical trial design; Nutraceuticals
Core Tip	This commentary reviews a clinical trial that investigated the combination of silymarin and alpha-lipoic acid, along with a Mediterranean diet, in patients with metabolic dysfunction-associated steatotic liver disease. Although some health improvements were noted, issues like small sample size, lack of a supplement-only group, and poor tracking of adherence make the results less reliable. The letter suggests future studies should use stronger designs, clear outcomes, balanced sex representation, and transparent reporting to improve the usefulness and accuracy of research findings.
Publish Date	2025-09-25 11:24
Citation	<p>Martínez-Sánchez FD, Martínez-Vázquez SE, Gutiérrez-Monterrubio R, Muñoz-Martínez S, Garcia-Juarez I. Silymarin-alpha lipoic acid and metabolic dysfunction-associated steatotic liver disease: Insights and methodological considerations. <i>World J Hepatol</i> 2025; 17(9): 110162</p>
URL	https://www.wjgnet.com/1948-5182/full/v17/i9/110162.htm
DOI	https://dx.doi.org/10.4254/wjh.v17.i9.110162

Full Article (PDF)	WJH-17-110162-with-cover.pdf
Manuscript File	110162_Auto_Edited_014742.docx
Answering Reviewers	110162-answering-reviewers.pdf
Audio Core Tip	110162-audio.mp4
Conflict-of-Interest Disclosure Form	110162-conflict-of-interest-statement.pdf
Copyright License Agreement	110162-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate	110162-non-native-speakers.pdf
Peer-review Report	110162-peer-reviews.pdf
Scientific Misconduct Check	110162-scientific-misconduct-check.png
Scientific Editor Work List	110162-scientific-editor-work-list.pdf
CrossCheck Report	110162-crosscheck-report.pdf