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Articles Published Processes
8/21/2025 8:16:40 AM | Browse: 42 | Download: 64
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Received |
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2025-05-30 01:41 |
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Peer-Review Started |
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2025-05-30 01:41 |
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To Make the First Decision |
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Return for Revision |
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2025-06-06 03:40 |
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Revised |
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2025-06-12 19:49 |
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Second Decision |
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2025-07-18 02:46 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-07-18 07:02 |
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Articles in Press |
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2025-07-18 07:02 |
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Publication Fee Transferred |
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2025-06-17 17:14 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-08-07 07:27 |
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Publish the Manuscript Online |
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2025-08-21 08:16 |
| ISSN |
1949-8462 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cardiac & Cardiovascular Systems |
| Manuscript Type |
Review |
| Article Title |
Integrative cardiovascular disease therapy: Linoleic acid restriction, enhanced external counterpulsation, and emerging nanotherapies
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Joseph Mercola |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Joseph Mercola, Researcher, /, Midwestern University, 555 31st Street, Downers Grove, IL 60515, United States. drm@mercola.com |
| Key Words |
Cardiovascular disease; Atherosclerosis; Integrative therapy; Linoleic acid reduction; Enhanced external counterpulsation; Nanoparticle-facilitated chelation; Metabolic optimization; Residual cardiovascular risk |
| Core Tip |
Cardiovascular disease (CVD) care still leaves a 20 % five-year major adverse cardiovascular event (MACE) risk. This review outlines an integrative, root-cause strategy combining dietary linoleic acid (LA) restriction ( < 5 g/day) to lower oxidized low-density lipoprotein (oxLDL), non-invasive enhanced external counterpulsation (EECP) to boost nitric-oxide–mediated perfusion, and plaque-targeted nanoliposomal chelation to reverse calcification. These scalable, affordable interventions collectively target oxidative stress, endothelial inflammation and plaque instability, offering a realistic roadmap to transform coronary events from commonplace to rare and potentially reshape future CVD management. |
| Publish Date |
2025-08-21 08:16 |
| Citation |
<p>Mercola J. Integrative cardiovascular disease therapy: Linoleic acid restriction, enhanced external counterpulsation, and emerging nanotherapies. <i>World J Cardiol</i> 2025; 17(8): 110163</p> |
| URL |
https://www.wjgnet.com/1949-8462/full/v17/i8/110163.htm |
| DOI |
https://dx.doi.org/10.4330/wjc.v17.i8.110163 |
© 2004-2025 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
California Corporate Number: 3537345
