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Articles Published Processes
11/27/2025 7:54:00 AM | Browse: 9 | Download: 6
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Received |
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2025-06-03 03:03 |
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Peer-Review Started |
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2025-06-03 03:03 |
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First Decision by Editorial Office Director |
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2025-06-23 01:40 |
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Return for Revision |
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2025-06-23 01:40 |
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Revised |
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2025-07-05 18:13 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-11-06 02:42 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-11-07 02:26 |
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Articles in Press |
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2025-11-07 02:26 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-11-17 01:05 |
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Publish the Manuscript Online |
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2025-11-27 07:54 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Review |
| Article Title |
Liver as a metabolic sensor in gestational diabetes: Implications for offspring’s liver and diabetes risk
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Mona Mohamed Ibrahim Abdalla and Mohammed Ismail-Khan |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Mona Mohamed Ibrahim Abdalla, MD, PhD, Department of Human Biology, School of Medicine, International Medical University, No. 126 Jln Jalil Perkasa 19, Bukit Jalil 57000, Kuala Lumpur, Malaysia. monamohamed@imu.edu.my |
| Key Words |
Insulin resistance in pregnancy; Intrauterine exposure; Epigenetic reprogramming; Fetal metabolic imprinting; Metabolic sensor; Liver; Hepatokines |
| Core Tip |
Gestational diabetes mellitus does not only affect maternal glucose metabolism, but it can also program lifelong metabolic vulnerabilities in the offspring. This article emphasizes the underappreciated role of the maternal liver as a metabolic sensor that detects pregnancy-related physiological stress and modulates systemic signals accordingly. When impaired by gestational diabetes mellitus, the maternal liver becomes a source of maladaptive endocrine, inflammatory, and metabolic cues that are transmitted to the fetus. These signals can reprogram fetal liver development and increase the risk of non-alcoholic fatty liver disease and type 2 diabetes mellitus in later life. Recognizing the liver’s central role in this process opens new avenues for preventive and therapeutic strategies targeting both maternal and offspring health. |
| Publish Date |
2025-11-27 07:54 |
| Citation |
Abdalla MMI, Ismail-Khan M. Liver as a metabolic sensor in gestational diabetes: Implications for offspring’s liver and diabetes risk. World J Hepatol 2025; 17(11): 110185 |
| URL |
https://www.wjgnet.com/1948-5182/full/v17/i11/110185.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v17.i11.110185 |
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