| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Plasma monocyte chemotactic protein-1 remains elevated after minimally invasive colorectal cancer resection
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
HMC Shantha Kumara, Elizabeth A Myers, Sonali AC Herath, Joon Ho Jang, Linda Njoh, Xiaohong Yan, Daniel Kirchoff, Vesna Cekic, Martin Luchtefeld and Richard L Whelan |
| Funding Agency and Grant Number |
|
| Corresponding Author |
Richard L Whelan, MD, Professor of Surgery, Chief, Colon and Rectal Surgery, Chief, Surgical Oncology, Department of Surgery, College of Physicians and Surgeons, Columbia University, 116th St and Broadway, New York, NY 10032, United States. rwhelan@chpnet.org |
| Key Words |
Colorectal cancer; Monocyte chemotactic protein-1; Minimally invasive colorectal resection angiogenesis |
| Core Tip |
In our past published studied we have shown that plasma levels of the pro-angiogenic proteins, vascular endothelial growth factor, angiopoietin-2, placental growth factor, and soluble vascular adhesion molecule-1, are significantly elevated for 2-4 wk following minimally invasive colorectal resection for colorectal cancer (CRC). Additionally, we also showed that postoperative plasma from cancer patients stimulates in vitro endothelial cell proliferation, migration, and invasion, all of which are critical steps in angiogenesis. In this manuscript we are presenting data to show that plasma Monocyte chemotactic protein-1 (MCP-1), a pro-angiogenic protein, in CRC patients remain elevated for month after MICR. Furthermore, we are also showing that the median preoperative plasma level of MCP-1 is significantly higher in the CRC patients than in the BEN group. |
| Publish Date |
2014-10-20 09:08 |
| Citation |
Shantha Kumara HMC, Myers EA, Herath SAC, Jang JH, Njoh L, Yan X, Kirchoff D, Cekic V, Luchtefeld M, Whelan RL. Plasma monocyte chemotactic protein-1 remains elevated after minimally invasive colorectal cancer resection. World J Gastrointest Oncol 2014; 6(10): 413-419 |
| URL |
http://www.wjgnet.com/1948-5204/full/v6/i10/413.htm |
| DOI |
http://dx.doi.org/10.4251/wjgo.v6.i10.413 |
