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Articles Published Processes
10/16/2025 9:32:19 AM | Browse: 225 | Download: 541
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Received |
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2025-06-03 16:04 |
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Peer-Review Started |
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2025-06-03 16:04 |
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First Decision by Editorial Office Director |
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2025-06-18 06:55 |
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Return for Revision |
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2025-06-18 06:55 |
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Revised |
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2025-06-27 02:21 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-09-19 02:44 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-09-19 11:59 |
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Articles in Press |
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2025-09-19 11:59 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-09-28 02:27 |
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Publish the Manuscript Online |
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2025-10-16 09:32 |
| ISSN |
2218-5836 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Orthopedics |
| Manuscript Type |
Randomized Controlled Trial |
| Article Title |
Efficacy and safety of pre-emptive tapentadol on pain control in total knee arthroplasty: A randomized, double-blind, placebo-controlled trial
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Samiksha Bhattacharjee, Anand Srinivasan, Sujit Kumar Tripathy, Sunil Kumar Doki and Debasish Hota |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Sujit Kumar Tripathy, Professor, Department of Orthopaedics, All India Institute of Medical Sciences, Sijua, Patrapada, Bhubaneswar 751019, Odisha, India. ortho_sujit@aiimsbhubaneswar.edu.in |
| Key Words |
Pain; Analgesic; Tramadol; Opioid; Arthroplasty; Multimodal analgesia; Preemptive analgesia; Knee; Total knee replacement; Total knee arthroplasty |
| Core Tip |
This randomized, double-blind, placebo-controlled trial evaluated the efficacy and safety of a single preemptive 100 mg dose of sustained-release tapentadol in patients undergoing total knee arthroplasty (TKA). Tapentadol significantly reduced postoperative pain scores, delayed the need for rescue analgesia, and lowered total analgesic consumption without increasing opioid-related side effects. Its plasma concentration correlated strongly with pain intensity, while cholecystokinin levels did not. With a favorable safety profile and analgesic efficacy, tapentadol may be a valuable component of multimodal analgesia in TKA, offering an opioid-sparing strategy with reduced gastrointestinal and central nervous system side effects. Further multicenter validation is warranted. |
| Publish Date |
2025-10-16 09:32 |
| Citation |
Bhattacharjee S, Srinivasan A, Tripathy SK, Doki SK, Hota D. Efficacy and safety of pre-emptive tapentadol on pain control in total knee arthroplasty: A randomized, double-blind, placebo-controlled trial. World J Orthop 2025; 16(10): 110233 |
| URL |
https://www.wjgnet.com/2218-5836/full/v16/i10/110233.htm |
| DOI |
https://dx.doi.org/10.5312/wjo.v16.i10.110233 |
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