Publication Name	World Journal of Orthopedics
Manuscript ID	110233
Country	India

Received	2025-06-03 16:04
Peer-Review Started	2025-06-03 16:04
To Make the First Decision
Return for Revision	2025-06-18 06:55
Revised	2025-06-27 02:21
Second Decision	2025-09-19 02:44
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-09-19 11:59
Articles in Press	2025-09-19 11:59
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-09-28 02:27
Publish the Manuscript Online	2025-10-16 09:32

ISSN	2218-5836 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Orthopedics
Manuscript Type	Randomized Controlled Trial
Article Title	Efficacy and safety of pre-emptive tapentadol on pain control in total knee arthroplasty: A randomized, double-blind, placebo-controlled trial
Manuscript Source	Invited Manuscript
All Author List	Samiksha Bhattacharjee, Anand Srinivasan, Sujit Kumar Tripathy, Sunil Kumar Doki and Debasish Hota
ORCID	Author(s) ORCID Number Sujit Kumar Tripathy http://orcid.org/0000-0003-0179-9910 Sunil Kumar Doki http://orcid.org/0000-0002-2448-7250
Funding Agency and Grant Number
Corresponding Author	Sujit Kumar Tripathy, Professor, Department of Orthopaedics, All India Institute of Medical Sciences, Sijua, Patrapada, Bhubaneswar 751019, Odisha, India. ortho_sujit@aiimsbhubaneswar.edu.in
Key Words	Pain; Analgesic; Tramadol; Opioid; Arthroplasty; Multimodal analgesia; Preemptive analgesia; Knee; Total knee replacement; Total knee arthroplasty
Core Tip	This randomized, double-blind, placebo-controlled trial evaluated the efficacy and safety of a single preemptive 100 mg dose of sustained-release tapentadol in patients undergoing total knee arthroplasty (TKA). Tapentadol significantly reduced postoperative pain scores, delayed the need for rescue analgesia, and lowered total analgesic consumption without increasing opioid-related side effects. Its plasma concentration correlated strongly with pain intensity, while cholecystokinin levels did not. With a favorable safety profile and analgesic efficacy, tapentadol may be a valuable component of multimodal analgesia in TKA, offering an opioid-sparing strategy with reduced gastrointestinal and central nervous system side effects. Further multicenter validation is warranted.
Publish Date	2025-10-16 09:32
Citation	<p>Bhattacharjee S, Srinivasan A, Tripathy SK, Doki SK, Hota D. Efficacy and safety of pre-emptive tapentadol on pain control in total knee arthroplasty: A randomized, double-blind, placebo-controlled trial. <i>World J Orthop</i> 2025; 16(10): 110233</p>
URL	https://www.wjgnet.com/2218-5836/full/v16/i10/110233.htm
DOI	https://dx.doi.org/10.5312/wjo.v16.i10.110233

Full Article (PDF)	WJO-16-110233-with-cover.pdf
CONSORT 2010 Statement	110233-CONSORT-2010-statement.pdf
Manuscript File	110233_Auto_Edited_092148.docx
Answering Reviewers	110233-answering-reviewers.pdf
Audio Core Tip	110233-audio.mp4
Biostatistics Review Certificate	110233-biostatistics-statement.pdf
Clinical Trial Registration Statement	110233-clinical-trial-registration-statement.pdf
Conflict-of-Interest Disclosure Form	110233-conflict-of-interest-statement.pdf
Copyright License Agreement	110233-copyright-assignment.pdf
Signed Informed Consent Form(s) or Document(s)	110233-informed-consent-statement.pdf
Institutional Review Board Approval Form or Document	110233-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate	110233-non-native-speakers.pdf
Supplementary Material	110233-supplementary-material.pdf
Peer-review Report	110233-peer-reviews.pdf
Scientific Misconduct Check	110233-scientific-misconduct-check.png
Scientific Editor Work List	110233-scientific-editor-work-list.pdf
CrossCheck Report	110233-crosscheck-report.pdf