| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Randomized Controlled Trial |
| Article Title |
Concomitant therapy achieved the best eradication rate for Helicobacter pylori among various treatment strategies
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Hyun Jeong Lee, Jin Il Kim, Jin Soo Lee, Eun Jung Jun, Jung-Hwan Oh, Dae Young Cheung, Woo Chul Chung, Byung-Wook Kim and Sung Soo Kim |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Education, Science and Technology |
2013R1A1A2062603 |
|
| Corresponding Author |
Jin Il Kim, MD, PhD, Division of Gastroenterology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, 62 Yeouido-dong, Yeongdeungpo-gu, Seoul 150-713, South Korea. jikim@catholic.ac.kr |
| Key Words |
Helicobacter pylori; Eradication; Drug resistance; Concomitant therapy; Sequential therapy |
| Core Tip |
A total 680 patients who were infected with Helicobacter pylori (H. pylori) were divided into 4 groups and each group was treated with a different eradication therapy. The eradication rates were 76.2%, 84.2%, 84.4% and 94.4% in the rabeprazole, amoxicillin and clarithromycin (PAC) group, the rabeprazole, amoxicillin and metronidazole group, the sequential group and the concomitant group. Comparing concomitant therapy and PAC therapy, the number needed to treat was 5.49. The eradication rate was 84.4% for the second-line therapy and 42.9% for the third-line therapy. The study was designed due to the high prevalence of H. pylori and gastric cancer and the recent marked increase in clarithromycin resistance. |
| Publish Date |
2015-01-07 11:07 |
| Citation |
Lee HJ, Kim JI, Lee JS, Jun EJ, Oh JH, Cheung DY, Chung WC, Kim BW, Kim SS. Concomitant therapy achieved the best eradication rate for Helicobacter pylori among various treatment strategies. World J Gastroenterol 2015; 21(1): 351-359 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i1/351.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i1.351 |
